2. Immunology/Inflammation
  3. Kallikrein
  4. KKI-5

KKI-5  (Synonyms: 激肽释放酶抑制剂)

目录号: HY-P0237
产品使用指南

摩尔计算器

KKI-5 是一种特异性的组织激肽释放酶 (kallikrein) 抑制剂。KKI-5 可降低乳腺癌细胞浸润。

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Custom Peptide Synthesis

KKI-5 Chemical Structure

KKI-5 Chemical Structure

CAS No. : 97145-43-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

KKI-5 的其他形式现货产品:

Customer Review

Other Forms of KKI-5:

KKI-5 相关抗体

Top Publications Citing Use of Products

查看 Kallikrein 亚型特异性产品:

查看所有亚型
KLK1 KLK5 KLK8 KLK14 KLKB1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KKI-5 is a specific inhibitor of tissue kallikrein. KKI-5 can attenuate breast cancer cell invasion[1].

IC50 & Target

Kallikrein Inhibitor
体外研究
(In Vitro)

The KKI-5 Peptide corresponds to aa386-391 of bovine kininogen-1 that encompasses the aa388-389 kallikrein proteolytic site. The synthetic KKI-5 can attenuate breast cancer cell invasion, therefore it is investigated for its role in invasion and metastasis of cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KKI-5 相关抗体:
分子量

773.88

Formula

C35H55N11O9
CAS 号
Sequence

Ac-Pro-Phe-Arg-Ser-Val-Gln-NH2
Sequence Shortening

Ac-PFRSVQ-NH2
中文名称

激肽释放酶抑制剂
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

KKI-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KKI-597145-43-2激肽释放酶抑制剂KKI5KKI 5KallikreinKLKKallikrein-related peptidasekallikreinbreast cancercell invasionInhibitorinhibitorinhibit

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目录号：
HY-P0237
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