2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Hisidine (monohydrocholoride)

L-Hisidine (monohydrocholoride)  (Synonyms: L-组氨酸盐酸盐)

目录号: HY-N0833
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L-Hisidine是婴儿必需的氨基酸。L-Hisidine是线粒体谷氨酰胺转运的抑制剂。

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L-Hisidine (monohydrocholoride) Chemical Structure

L-Hisidine (monohydrocholoride) Chemical Structure

CAS No. : 645-35-2

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L-Hisidine (monohydrocholoride) 的其他形式现货产品:

Other Forms of L-Hisidine (monohydrocholoride):

L-Hisidine (monohydrocholoride) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-Hisidine is an essential amino acid for infants. L-Hisidine is an inhibitor of mitochondrial glutamine transport.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

L-histidine completely inhibits growth and its effect on viability is inversely related to FLO11 expression. L-histidine does not affect the viability of the Δflo11 and S288c strains. L-histidine dramatically decreases air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the FLO11 gene. Moreover, L-histidine modifies the chitin and glycans content on the cell-wall of flor yeasts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-Hisidine (monohydrocholoride) 相关抗体:
体内研究
(In Vivo)

L-histidine (100 mg/kg) completely inhibits the brain edema in thioacetamide-treated rats[2]. Histamine release stimulated by high K+ from the hypothalamus in the L-histidine diet group is 60% of that in the control group. However, the concentrations of other monoamines and their metabolites are not changed by the L-histidine diet. The open-field tests show that the L-histidine diet group spends a shorter amount of time in the central zone, and the light/dark box tests demonstrate that the L-histidine diet group spends a shorter amount of time in the light box, suggesting that the L-histidine diet induced anxiety-like behaviors[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

191.62

Formula

C6H10ClN3O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

L-组氨酸盐酸盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献
Animal Administration
[2][3]

Rats: TAA (300 mg/kg i.p) is given to animals daily for 3 days. L-histidine (100 mg/kg) is dissolved in saline and injected (i.p.) daily 2 hours before each TAA injection. To prevent hypoglycemia and dehydration, rats are given 12.5 ml/kg of fluid therapy (5% dextrose and 0.45% saline with 20 mEq/L of potassium chloride) every 12 hours, s.c. Normal controls receive saline (vehicle used for TAA), whereas another group of rats are given L-histidine alone (100 mg/kg) daily for 3 days. TAA-treated rats are clinically monitored, and stages of encephalopathy are graded[2]. Mice: The control group is fed with the AIN-93G purified diet that contains 5.08 g L-histidine/kg, whereas the L-histidine diet group is fed with AIN-93G that contains 1.28 g L-histidine/kg (25% of the histidine content in AIN-93G). To equalize the total amount of amino acids, glutamine is added to the L-histidine diet to counterbalance the changes in the histidine content (18.32 g L-glutamine/kg AIN-93G vs. 23.72 g L-glutamine/kg L-histidine diet). Both diets are isonitrogenous. At 8 wk of age, the mice are weighed and assigned to 2 different diets. The mice are allowed ad libitum access to water and their respective diets, and they are housed for at least 2 wk in the laboratory before starting the experiments[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

L-Hisidine (monohydrocholoride) 相关分类

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Keywords:

L-Hisidine (monohydrocholoride)645-35-2L-组氨酸盐酸盐Endogenous MetaboliteInhibitorinhibitorinhibit

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