L-Histidine (Synonyms: L-组氨酸)

目录号: HY-N0832 纯度: 99.81%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

L-Histidine 是婴儿必需的氨基酸。L-Histidine 是线粒体谷氨酰胺转运的抑制剂。

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L-Histidine Chemical Structure

CAS No. : 71-00-1

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规格	价格	是否有货
10 mM * 1 mL in Water	￥500	In-stock
500 mg	￥400	In-stock
1 g	￥500	In-stock
5 g		询价
10 g		询价

or 大包装询价

* Please select Quantity before adding items.

Customer Review

Other Forms of L-Histidine:

L-Histidine hydrochloride hydrate In-stock
L-Histidine-¹⁵N₃ 询价
L-Histidine-13C6,15N3 询价
L-Histidine-¹³C₆,¹⁵N₃ hydrochloride 询价
L-Hisidine (monohydrocholoride) 询价
L-Histidine dihydrochloride 询价
L-Histidine (Standard) 询价

MCE 顾客使用本产品发表的 2 篇科研文献

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生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

体外研究
(In Vitro)

L-Histidine 完全抑制生长，其对活力的影响与 FLO11 表达呈负相关。L-Histidine 不影响 Δflo11 和 S288c 菌株的活力。L-Histidine 显著降低气液生物膜形成和弗洛尔酵母对聚苯乙烯的粘附，而对 FLO11 基因的转录水平没有影响。此外，L-Histidine 可修饰 flor 酵母细胞壁上的几丁质和聚糖含量^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

L-histidine (100 mg/kg) 完全抑制硫代乙酰胺处理的大鼠的脑水肿^[2]。L-Histidine 饮食组下丘脑高 K⁺ 刺激下的组胺释放是对照组的 60%。然而，L-Histidine 饮食不会改变其他单胺及其代谢物的浓度。旷场测试表明，L-Histidine 饮食组在中心区停留的时间较短，而光/暗箱测试表明，L-Histidine 饮食组在灯箱中停留的时间较短，表明 L-Histidine 饮食会诱发焦虑样行为^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

155.15

Formula

C₆H₉N₃O₂

CAS 号

71-00-1

性状

固体

颜色

White to off-white

中文名称

L-组氨酸

结构分类

Amino acids

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at room temperature 3 years

In solvent	-80°C	1 year
	-20°C	6 months

溶解性数据

细胞实验：

H₂O 中的溶解度 : 20.83 mg/mL (134.26 mM; 超声助溶 (<80°C))

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.4454 mL	32.2269 mL	64.4538 mL
5 mM	1.2891 mL	6.4454 mL	12.8908 mL
10 mM	0.6445 mL	3.2227 mL	6.4454 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用， -20°C储存时，请在6个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

请依序添加每种溶剂： PBS
Solubility: 25 mg/mL (161.13 mM); 澄清溶液; 超声助溶

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测水 / PBS / Saline 中的溶解度数据。

您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。

纯度 & 产品资料

纯度: 99.81%

选择批次：

Data Sheet (641 KB) SDS (393 KB)

COA (284 KB) LCMS (89 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141. [Content Brief]

[2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8. [Content Brief]

[3]. Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144(10):1637-41. [Content Brief]

Animal Administration ^[2]^[3]	Rats: TAA (300 mg/kg i.p) is given to animals daily for 3 days. L-histidine (100 mg/kg) is dissolved in saline and injected (i.p.) daily 2 hours before each TAA injection. To prevent hypoglycemia and dehydration, rats are given 12.5 ml/kg of fluid therapy (5% dextrose and 0.45% saline with 20 mEq/L of potassium chloride) every 12 hours, s.c. Normal controls receive saline (vehicle used for TAA), whereas another group of rats are given L-histidine alone (100 mg/kg) daily for 3 days. TAA-treated rats are clinically monitored, and stages of encephalopathy are graded^[2]. Mice: The control group is fed with the AIN-93G purified diet that contains 5.08 g L-histidine/kg, whereas the L-histidine diet group is fed with AIN-93G that contains 1.28 g L-histidine/kg (25% of the histidine content in AIN-93G). To equalize the total amount of amino acids, glutamine is added to the L-histidine diet to counterbalance the changes in the histidine content (18.32 g L-glutamine/kg AIN-93G vs. 23.72 g L-glutamine/kg L-histidine diet). Both diets are isonitrogenous. At 8 wk of age, the mice are weighed and assigned to 2 different diets. The mice are allowed ad libitum access to water and their respective diets, and they are housed for at least 2 wk in the laboratory before starting the experiments^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141. [Content Brief] [2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8. [Content Brief] [3]. Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144(10):1637-41. [Content Brief]

Animal Administration
^[2]^[3]

Rats: TAA (300 mg/kg i.p) is given to animals daily for 3 days. L-histidine (100 mg/kg) is dissolved in saline and injected (i.p.) daily 2 hours before each TAA injection. To prevent hypoglycemia and dehydration, rats are given 12.5 ml/kg of fluid therapy (5% dextrose and 0.45% saline with 20 mEq/L of potassium chloride) every 12 hours, s.c. Normal controls receive saline (vehicle used for TAA), whereas another group of rats are given L-histidine alone (100 mg/kg) daily for 3 days. TAA-treated rats are clinically monitored, and stages of encephalopathy are graded^[2].

Mice: The control group is fed with the AIN-93G purified diet that contains 5.08 g L-histidine/kg, whereas the L-histidine diet group is fed with AIN-93G that contains 1.28 g L-histidine/kg (25% of the histidine content in AIN-93G). To equalize the total amount of amino acids, glutamine is added to the L-histidine diet to counterbalance the changes in the histidine content (18.32 g L-glutamine/kg AIN-93G vs. 23.72 g L-glutamine/kg L-histidine diet). Both diets are isonitrogenous. At 8 wk of age, the mice are weighed and assigned to 2 different diets. The mice are allowed ad libitum access to water and their respective diets, and they are housed for at least 2 wk in the laboratory before starting the experiments^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141. [Content Brief]

[2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8. [Content Brief]

[3]. Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144(10):1637-41. [Content Brief]

L-Histidine 相关分类

Neurological Disease Metabolic Disease Inflammation/Immunology

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	6.4454 mL	32.2269 mL	64.4538 mL	161.1344 mL
	5 mM	1.2891 mL	6.4454 mL	12.8908 mL	32.2269 mL
	10 mM	0.6445 mL	3.2227 mL	6.4454 mL	16.1134 mL
	15 mM	0.4297 mL	2.1485 mL	4.2969 mL	10.7423 mL
	20 mM	0.3223 mL	1.6113 mL	3.2227 mL	8.0567 mL
	25 mM	0.2578 mL	1.2891 mL	2.5782 mL	6.4454 mL
	30 mM	0.2148 mL	1.0742 mL	2.1485 mL	5.3711 mL
	40 mM	0.1611 mL	0.8057 mL	1.6113 mL	4.0284 mL
	50 mM	0.1289 mL	0.6445 mL	1.2891 mL	3.2227 mL
	60 mM	0.1074 mL	0.5371 mL	1.0742 mL	2.6856 mL
	80 mM	0.0806 mL	0.4028 mL	0.8057 mL	2.0142 mL
	100 mM	0.0645 mL	0.3223 mL	0.6445 mL	1.6113 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Histidine71-00-1L-组氨酸Mitochondrial MetabolismEndogenous MetaboliteInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

L-Histidine (Synonyms: L-组氨酸)

Customer Review

Other Forms of L-Histidine:

MCE 顾客使用本产品发表的 2 篇科研文献