2. Metabolic Enzyme/Protease Anti-infection
  3. Aminoacyl-tRNA Synthetase Bacterial
  4. Leu-AMS

Leu-AMS (compound 6)，亮氨酸类似物，是一种有效的亮氨酰-tRNA 合成酶 (LRS) 抑制剂，IC50 值为 22.34 nM，Leu-AMS 抑制了LRS 的催化活性，但不影响亮氨酸诱导的 mTORC1 活化。Leu-AMS在癌细胞和正常细胞中显示出细胞毒性，并抑制细菌的生长。

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Leu-AMS Chemical Structure

Leu-AMS Chemical Structure

CAS No. : 288591-93-5

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规格 价格 是否有货 数量
1 mg ￥1900
In-stock
5 mg ￥5900
In-stock
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100 mg   询价  

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Customer Review

Other Forms of Leu-AMS:

Leu-AMS 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria[1].

IC50 & Target

IC50: 22.34 nM (LRS)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.59 μM
Compound: 6
Cytotoxicity in human A549 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human A549 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
HCT-116 IC50
0.24 μM
Compound: 6
Cytotoxicity in human HCT-116 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human HCT-116 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
K562 IC50
0.4 μM
Compound: 6
Cytotoxicity in human K562 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human K562 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
MDA-MB-231 IC50
0.73 μM
Compound: 6
Cytotoxicity in human MDA-MB-231 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human MDA-MB-231 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
MRC5 IC50
5.9 μM
Compound: 6
Cytotoxicity in human MRC5 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human MRC5 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
SK-HEP1 IC50
0.54 μM
Compound: 6
Cytotoxicity in human SK-HEP1 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human SK-HEP1 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
SNU-638 IC50
0.84 μM
Compound: 6
Cytotoxicity in human SNU-638 cells by sulforhodamine B colorimetric assay
Cytotoxicity in human SNU-638 cells by sulforhodamine B colorimetric assay
[PMID: 27933890]
体外研究
(In Vitro)

Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC50 value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Leu-AMS 相关抗体:
分子量

459.48

Formula

C16H25N7O7S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 49.17 mg/mL (107.01 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1764 mL 10.8819 mL 21.7637 mL
5 mM 0.4353 mL 2.1764 mL 4.3527 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Leu-AMS 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1764 mL 10.8819 mL 21.7637 mL 54.4093 mL
5 mM 0.4353 mL 2.1764 mL 4.3527 mL 10.8819 mL
10 mM 0.2176 mL 1.0882 mL 2.1764 mL 5.4409 mL
15 mM 0.1451 mL 0.7255 mL 1.4509 mL 3.6273 mL
20 mM 0.1088 mL 0.5441 mL 1.0882 mL 2.7205 mL
25 mM 0.0871 mL 0.4353 mL 0.8705 mL 2.1764 mL
30 mM 0.0725 mL 0.3627 mL 0.7255 mL 1.8136 mL
40 mM 0.0544 mL 0.2720 mL 0.5441 mL 1.3602 mL
50 mM 0.0435 mL 0.2176 mL 0.4353 mL 1.0882 mL
60 mM 0.0363 mL 0.1814 mL 0.3627 mL 0.9068 mL
80 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6801 mL
100 mM 0.0218 mL 0.1088 mL 0.2176 mL 0.5441 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leu-AMS288591-93-5Aminoacyl-tRNA SynthetaseBacterialtRNA Synthetase, aaRSInhibitorinhibitorinhibit

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目录号：
HY-108900
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