2. Vitamin D Related/Nuclear Receptor
  3. VD/VDR
  4. Lexacalcitol

Lexacalcitol  (Synonyms: 来沙骨化醇; KH1060)

目录号: HY-32340 纯度: 99.42%
COA 产品使用指南

摩尔计算器

Lexacalcitol (KH1060) 是一种维生素 D 类似物，是细胞生长和免疫反应的有效调节剂。Lexacalcitol 可用于移植排斥反应、银屑病、癌症和自身免疫性疾病的研究。

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Lexacalcitol Chemical Structure

Lexacalcitol Chemical Structure

CAS No. : 131875-08-6

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规格 价格 是否有货 数量
1 mg ￥2560
In-stock
5 mg 现货 询价
10 mg   询价  
50 mg   询价  

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Customer Review

Lexacalcitol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lexacalcitol (KH1060), a vitamin D analog, is a potent regulator of cell growth and immune responses. Lexacalcitol can be used for the research of graft rejection, psoriasis, cancer and auto-immune diseases[1][2].

体外研究
(In Vitro)

Lexacalcitol inhibits cell proliferation by 50% at 10-12 M (14,000 times more active than la,25(OH)2D3) in human histiocytic lymphoma cell line U 937[1].
Lexacalcitol inhibits interleukin-1-induced mouse thymocyte proliferation by 50% at 3×10-16 M , allogeneic stimulation of mouse spleen lymphocytes at 5×10-15 M[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lexacalcitol 相关抗体:
体内研究
(In Vivo)

Lexacalcitol (0.5 mg/kg/2 days; i.p.) in combination with cyclosporin A (CyA) can prevent autoimmune destruction of syngeneic islet grafts in spontaneously diabetic NOD recipients[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female spontaneously diabetic NOD mice[2]
Dosage: 0.5 mg/kg/2 days
Administration: Intraperitoneal injection
Result: Single treatment with KH1060 or CyA did not result in statistically significant suppression of early graft failure, while the combination of KH1060 and CyA can prevent early graft failure and delay graft rejection of xenogeneic islets in spontaneously diabetic NOD mice.
分子量

460.69

Formula

C29H48O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

来沙骨化醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (217.07 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1707 mL 10.8533 mL 21.7066 mL
5 mM 0.4341 mL 2.1707 mL 4.3413 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Lexacalcitol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1707 mL 10.8533 mL 21.7066 mL 54.2664 mL
5 mM 0.4341 mL 2.1707 mL 4.3413 mL 10.8533 mL
10 mM 0.2171 mL 1.0853 mL 2.1707 mL 5.4266 mL
15 mM 0.1447 mL 0.7236 mL 1.4471 mL 3.6178 mL
20 mM 0.1085 mL 0.5427 mL 1.0853 mL 2.7133 mL
25 mM 0.0868 mL 0.4341 mL 0.8683 mL 2.1707 mL
30 mM 0.0724 mL 0.3618 mL 0.7236 mL 1.8089 mL
40 mM 0.0543 mL 0.2713 mL 0.5427 mL 1.3567 mL
50 mM 0.0434 mL 0.2171 mL 0.4341 mL 1.0853 mL
60 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.9044 mL
80 mM 0.0271 mL 0.1357 mL 0.2713 mL 0.6783 mL
100 mM 0.0217 mL 0.1085 mL 0.2171 mL 0.5427 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lexacalcitol131875-08-6KH1060来沙骨化醇KH 1060KH-1060VD/VDRVitamin DVitamin D receptorantiproliferativecelldifferentiating1a,25-(OH)2D3immunosuppressiveauto-immunediseasespsoriasispreventiongraftrejectionInhibitorinhibitorinhibit

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目录号：
HY-32340
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