2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. MK-0674

MK-0674 是一种有效、可口服、选择性的 cathepsin K 抑制剂，IC50 值为 0.4 nM，对其选择性分别是 Cat B，Cat F，Cat L 和 Cat S 的 1156，1465，11857 和 243 倍。

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MK-0674 Chemical Structure

MK-0674 Chemical Structure

CAS No. : 887781-62-6

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

MK-0674 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1].

IC50 & Target

IC50: 0.4 nM (Cathepsin K)[1]
体外研究
(In Vitro)

MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MK-0674 相关抗体:
分子量

527.50

Formula

C26H27F6N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MK-0674 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-0674887781-62-6MK0674MK 0674CathepsinInhibitorinhibitorinhibit

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产品名称：
MK-0674
目录号：
HY-10290
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