2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs) ADC Linker
  4. Macropa-NCS

Macropa-NCS 能与抗体偶联形成肿瘤选择性载体分子，可以进一步与放射性核素结合作为特定靶向癌细胞载体，是靶向 α 研究(targeted alpha therapy，TAT) 中的连接子-螯合剂。

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Macropa-NCS Chemical Structure

Macropa-NCS Chemical Structure

CAS No. : 2146095-31-8

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Other Forms of Macropa-NCS:

Macropa-NCS 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Radionuclide-Drug Conjugates (RDCs) 亚型特异性产品:

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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Macropa-NCS can be coupled with antibodies to form tumor-selective carrier molecules, which can be further combined with radionuclides as specific targeting cancer cell carriers, and is a linker-chelating agent in targeted alpha research (TAT)[1].

IC50 & Target

RDC Linker

 

体外研究
(In Vitro)

A stock solution containing 4.4 mg/mL of macropa-NCS was prepared in 0.1 M pH 9.1 NaHCO3 buffer containing 0.154 M NaCl and was stored at -80 °C. To a portion of Tmab in saline (74 μL) were added macropa-NCS (52 μL) and NaHCO3 buffer (266 μL), so that the final concentrations of Tmab and macropa-NCS were 5.1 mg/mL and 0.59 mg/mL, respectively. Macropa-NCS was estimated to be in 16-fold molar excess to Tmab based on a molecular weight of 1045.76 g/mol for macropa-NCS (tetra-TFA salt)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Macropa-NCS 相关抗体:
分子量

589.66

Formula

C27H35N5O8S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Macropa-NCS 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Macropa-NCS2146095-31-8Radionuclide-Drug Conjugates (RDCs)ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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目录号：
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