2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Oxitropium Bromide

Oxitropium Bromide  (Synonyms: 氧托溴铵)

目录号: HY-U00105
产品使用指南

摩尔计算器

Oxitropium bromide 是毒蕈碱受体拮抗剂。Oxitropium bromide 具有抗胆碱能支气管扩张作用，能用于哮喘和慢性阻塞性肺疾病的研究。

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Oxitropium Bromide Chemical Structure

Oxitropium Bromide Chemical Structure

CAS No. : 30286-75-0

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规格 价格 是否有货 数量
5 mg ￥990
3 - 4 周
10 mg ￥1575
3 - 4 周
25 mg ￥3150
3 - 4 周
50 mg   询价  
100 mg   询价  

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Oxitropium Bromide 相关抗体

Top Publications Citing Use of Products

查看 mAChR 亚型特异性产品:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxitropium bromide is an mAChR antagonist used as an anticholinergic bronchodilator agent for the treatment of asthma and chronic obstructive pulmonary disease.

IC50 & Target

mAChR[1]
体外研究
(In Vitro)

Oxitropium bromide is a muscarinic antagonist which blocks musucarinic acetylcholine receptors (mAChR). Incubation with oxitropium bromide of untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro; however, it causes both types of muscle to be fatigue resistant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oxitropium Bromide 相关抗体:
体内研究
(In Vivo)

Oxitropium bromide inhalation shifts force-frequency curves upward at 2 h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection in vivo[1]. Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance. The increase in resistance induced by histamine, serotonin, leukotriene D4 or antigen is prevented by oxitropium bromide oxitropium bromide[2]. Inhalation of the anticholinergic agent oxitropium bromide at doses of 1.5 μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

412.32

Formula

C19H26BrNO4
CAS 号
中文名称

氧托溴铵；乙溴东莨菪碱；溴乙东碱
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice: In the oxitropium bromide inhalation group, animals are given 2 puffs of inhalation from a oxitropium bromide MDI (metered dose inhaler) via a 75-mL spacer, and then diaphragm muscles are dissected and measured as to contractility immediately, 1 hour, 2 hours and 4 hours later (n=5 animals each). An animal is placed in a centrifugal tube (inner diameter=30 mm) with a round hole (diameter=10 mm) in the bottom, its nose and mouth being exposed through the hole to breath. An oxitropium bromide MDI (metered dose inhaler) releases 2 puffs into a spacer attached to the tube. Aerosols of oxitropium bromide are inhaled for about 10 seconds, while the animal is breathing spontaneously through the hole of the tube[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Oxitropium Bromide 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxitropium30286-75-0氧托溴铵乙溴东莨菪碱溴乙东碱mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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