2. Anti-infection
  3. HIV
  4. Peptide T

Peptide T是源自HIV-1 gp120的V2区的八肽。 Peptide T是 CD4 受体的配体，可阻止 HIV 与CD4受体结合。

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Custom Peptide Synthesis

Peptide T Chemical Structure

Peptide T Chemical Structure

CAS No. : 106362-32-7

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规格 价格 是否有货 数量
1 mg ￥1000
In-stock
5 mg ￥2900
In-stock
10 mg ￥4900
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Peptide T:

Peptide T 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

查看所有亚型
HIV HIV-1 HIV-2

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.

IC50 & Target

CD4, HIV[1]
体外研究
(In Vitro)

Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4[2]. Peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10-9 M concentration significantly inhibits IFN-g production by PBMC[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Peptide T 相关抗体:
体内研究
(In Vivo)

Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

857.86

Formula

C35H55N9O16
CAS 号
性状

固体

颜色

White to off-white

Sequence

Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr
Sequence Shortening

ASTTTNYT
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (116.57 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1657 mL 5.8285 mL 11.6569 mL
5 mM 0.2331 mL 1.1657 mL 2.3314 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Cell Assay
[3]

Peripheral blood mononuclear cells are stimulated with PHA (5 mg/mL) along with various concentrations of peptide T (10-6-10-12 M) for 48 h at 37°C. Supernatants are collected and frozen until analysis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[4]

Rats[4]

Peptide T (125, 250, 500, 800 μg) is randomly given subcutaneously to Female Lewis rats aged 6-8 weeks in the hind foot flanks in a final volume of 0.2 mL. Control animals receive the same volume of saline alone[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Peptide T 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1657 mL 5.8285 mL 11.6569 mL 29.1423 mL
5 mM 0.2331 mL 1.1657 mL 2.3314 mL 5.8285 mL
10 mM 0.1166 mL 0.5828 mL 1.1657 mL 2.9142 mL
15 mM 0.0777 mL 0.3886 mL 0.7771 mL 1.9428 mL
20 mM 0.0583 mL 0.2914 mL 0.5828 mL 1.4571 mL
25 mM 0.0466 mL 0.2331 mL 0.4663 mL 1.1657 mL
30 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.9714 mL
40 mM 0.0291 mL 0.1457 mL 0.2914 mL 0.7286 mL
50 mM 0.0233 mL 0.1166 mL 0.2331 mL 0.5828 mL
60 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.4857 mL
80 mM 0.0146 mL 0.0729 mL 0.1457 mL 0.3643 mL
100 mM 0.0117 mL 0.0583 mL 0.1166 mL 0.2914 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peptide T106362-32-7HIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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目录号：
HY-P0272
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