2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Vitamin A

Vitamin A  (Synonyms: Vitamin A1; all-trans-Retinol)

目录号: HY-B1342 纯度: 99.27%
COA 产品使用指南 技术支持

Vitamin A (Vitamin A1) 是一种内源性代谢产物。

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Vitamin A Chemical Structure

Vitamin A Chemical Structure

CAS No. : 68-26-8

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规格 价格 是否有货 数量
5 mg ￥680
In-stock
10 mg ￥1100
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of Vitamin A:

Vitamin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vitamin A (Vitamin A1) is an endogenous metabolite.

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

It is found that contribution of hepatic microsomes (RDHs) to Retinol metabolism is greater than that of cytosol (ADHs), evidenced by higher Clint (Vmax/Km) of Vitamin A formation in microsomes than in cytosol[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vitamin A 相关抗体:
体内研究
(In Vivo)

The results show that compare with control (CON) rats, high-fat diet (HFD) significantly lowers basal level of Vitamin Al in plasma, but markedly elevates basal levels of Retinol in kidney, adipose tissue and liver. The results show that Vitamin Al absorption in HFD rats is faster than that in CON rats, evidenced by significantly shorter Tmax (3.0±0.0 h for HFD rats vs 5.8±1.1 h for CON rats, p<0.05)[1]. The plasma Vitamin A levels in methionine-choline deficient diet (MCD) rats are significantly lower than in the controls while the hepatic Vitamin A levels in MCD rats are markedly higher. The hepatic expression of Retinol-metabolizing enzymes and binding proteins (GRBP-I, ALDH1A1, and ALDH1A2) in MCD rats is significantly higher than that in control rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

286.45

Formula

C20H30O
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

视黄醇；维生素A1
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据
细胞实验： 

Ethanol 中的溶解度 : 100 mg/mL (349.10 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.4910 mL 17.4551 mL 34.9101 mL
5 mM 0.6982 mL 3.4910 mL 6.9820 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.27%

COA (282 KB) HNMR (244 KB) LCMS (94 KB)

产品使用指南 (1538 KB)
参考文献
Kinase Assay
[1]

Activity of alcohol dehydrogenases (ADHs)/retinol dehydrogenases (RDHs) and retinal dehydrogenases (RALDHs) are assessed. Briefly, hepatic ADHs/RDHs and RALDHs activities are evaluated with Retinal formation in the presence of β-nicotinamide adenine dinucleotide (β-NAD+) and β-Nicotinamide adenine dinucleotide phosphate (β-NADP+), respectively. The incubation mixture consists of hepatic cytosol/microsomes (at the final concentration of 0.5 mg/mL), and a series concentrations of Retinol, 4.0 mM co-factor, 5 mM MgCl2, 91 μM butylated hydroxytoluene in a total volume of 500 μL. The reaction is initiated by the addition of Retinol pre-incubated for 5 min at 37°C. Following 15 min incubation, the reaction is quenched by extraction with equal volume of n-butanol/methanol, 95:5 (v:v) containing 0.005% butylated hydroxytoluene[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[2]

Wistar rats (male, aged 4 wk) are used in this study. Two groups of 6 rats are given free access to the following diets: the standard diet (control group) and the methionine-choline deficient diet (MCD) group. Each diet contains Retinol (1000 IU/100g). After 6 wk, the rats are sacrificed by exsanguination under isoflurane anesthesia after an overnight fast. Blood is collected in heparinized tubes, and plasma is separated for storage at -80°C. The liver, intestine, testes, and kidneys are removed, immediately frozen in liquid nitrogen, and stored at -80°C[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Vitamin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.4910 mL 17.4551 mL 34.9101 mL 87.2753 mL
5 mM 0.6982 mL 3.4910 mL 6.9820 mL 17.4551 mL
10 mM 0.3491 mL 1.7455 mL 3.4910 mL 8.7275 mL
15 mM 0.2327 mL 1.1637 mL 2.3273 mL 5.8184 mL
20 mM 0.1746 mL 0.8728 mL 1.7455 mL 4.3638 mL
25 mM 0.1396 mL 0.6982 mL 1.3964 mL 3.4910 mL
30 mM 0.1164 mL 0.5818 mL 1.1637 mL 2.9092 mL
40 mM 0.0873 mL 0.4364 mL 0.8728 mL 2.1819 mL
50 mM 0.0698 mL 0.3491 mL 0.6982 mL 1.7455 mL
60 mM 0.0582 mL 0.2909 mL 0.5818 mL 1.4546 mL
80 mM 0.0436 mL 0.2182 mL 0.4364 mL 1.0909 mL
100 mM 0.0349 mL 0.1746 mL 0.3491 mL 0.8728 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vitamin A68-26-8Vitamin A1 all-trans-Retinol视黄醇维生素A1Vitamin A 1Vitamin A-1Endogenous MetaboliteInhibitorinhibitorinhibit

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