2. Anti-infection
  3. Bacterial
  4. Ribocil-C Racemate

Ribocil-C Racemate 是Ribocil-C的外消旋体。Ribocil-C是高度选择性的细菌核黄素核糖开关 (bacterial riboflavin riboswitches) 抑制剂。

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Ribocil-C Racemate Chemical Structure

Ribocil-C Racemate Chemical Structure

CAS No. : 2309762-18-1

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Customer Review

Other Forms of Ribocil-C Racemate:

Ribocil-C Racemate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ribocil-C Racemate is the racemate of Ribocil-C. Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

IC50 & Target

Bacterial riboflavin riboswitches[1]
体外研究
(In Vitro)

Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis[1]. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ribocil-C Racemate 相关抗体:
体内研究
(In Vivo)

Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

419.50

Formula

C21H21N7OS
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 30 mg/mL (71.51 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3838 mL 11.9190 mL 23.8379 mL
5 mM 0.4768 mL 2.3838 mL 4.7676 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (263 KB) HNMR (205 KB) LCMS (510 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[2]

DBA/2J mice are infected by intraperitoneal injectionwith Escherichia coli strain MB5746 (5×104 CFU per mouse) and treated by subcutaneous injection with Ribocil-C (30, 60, 120 mg/kg) or ciprofloxacin (0.5mg/kg) three times over a 24 h infection period. Spleens are aseptically collected from five mice per group and the reduction of log[CFU per g spleen tissue] is calculated on the basis of bacterial burden in spleens of the vehicle-treated (10% DMSO) control group[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Ribocil-C Racemate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3838 mL 11.9190 mL 23.8379 mL 59.5948 mL
5 mM 0.4768 mL 2.3838 mL 4.7676 mL 11.9190 mL
10 mM 0.2384 mL 1.1919 mL 2.3838 mL 5.9595 mL
15 mM 0.1589 mL 0.7946 mL 1.5892 mL 3.9730 mL
20 mM 0.1192 mL 0.5959 mL 1.1919 mL 2.9797 mL
25 mM 0.0954 mL 0.4768 mL 0.9535 mL 2.3838 mL
30 mM 0.0795 mL 0.3973 mL 0.7946 mL 1.9865 mL
40 mM 0.0596 mL 0.2980 mL 0.5959 mL 1.4899 mL
50 mM 0.0477 mL 0.2384 mL 0.4768 mL 1.1919 mL
60 mM 0.0397 mL 0.1986 mL 0.3973 mL 0.9932 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ribocil-C2309762-18-1BacterialInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-19488
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