2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. SNT-207858

SNT-207858 是一种选择性，可渗透血脑屏障的，有口服活性的黑皮质素 (melanocortin; MC-4) 受体拮抗剂，SNT-207858 抑制与 MC-4 受体结合，IC50 为 22 nM。SNT-207858 抑制 MC-4 活性，IC50 为 11 nM。

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SNT-207858 Chemical Structure

SNT-207858 Chemical Structure

CAS No. : 1104080-42-3

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SNT-207858 的其他形式现货产品:

Customer Review

Other Forms of SNT-207858:

SNT-207858 相关抗体

Top Publications Citing Use of Products

查看 Melanocortin Receptor 亚型特异性产品:

查看所有亚型
MC1R MC3R MC2R MC4R MC5R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].

IC50 & Target

IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1]
体外研究
(In Vitro)

SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SNT-207858 相关抗体:
体内研究
(In Vivo)

SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with C26 adenocarcinoma-induced cachexia model[1]
Dosage: 30 mg/kg
Administration: Oral administration; once daily; 15 days
Result: Significantly reduced the tumor induced weight loss.
分子量

689.54

Formula

C32H45Cl4N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SNT-207858 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNT-2078581104080-42-3SNT207858SNT 207858Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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产品名称：
SNT-207858
目录号：
HY-11030
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