2. Anti-infection
  3. Arenavirus
  4. ST-193 hydrochloride

ST-193 hydrochloride 

目录号: HY-101441A 纯度: 98.76%
COA 产品使用指南

摩尔计算器

ST-193 hydrochloride是有效广谱的arenavirus抑制剂；抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。

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ST-193 hydrochloride Chemical Structure

ST-193 hydrochloride Chemical Structure

CAS No. : 2320274-72-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2640
In-stock
1 mg ￥1160
In-stock
5 mg ￥2400
In-stock
10 mg ￥3600
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of ST-193 hydrochloride:

ST-193 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.

IC50 & Target

IC50: 0.44 nM (Guanarito), 0.62 nM (Junin), 1.4 nM (Lassa) and 3.1 nM (Machupo)[1]
体外研究
(In Vitro)

ST-193 inhibits LASV pseudotypes with an IC50 of 1.6 nM. ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC50s for Junín, Machupo, Guanarito, and Sabiá are in the 0.2 to 12 nM range) but exhibits no antiviral activity against pseudotypes incorporating either the GP from the LASV-related arenavirus lymphocytic choriomeningitis virus or the unrelated G protein from vesicular stomatitis virus, at concentrations of up to 10 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ST-193 hydrochloride 相关抗体:
体内研究
(In Vivo)

ST-193 is found to be tolerated well when administered daily as an intraperitoneal injection of either 25 or 100 mg/kg/day for 14 days. ST-193-treated animals exhibit fewer signs of disease and enhance survival when compared to the ribavirin or vehicle groups. Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

407.94

Formula

C24H26ClN3O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 150 mg/mL (367.70 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4513 mL 12.2567 mL 24.5134 mL
5 mM 0.4903 mL 2.4513 mL 4.9027 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[3]

Guinea pigs: ST-193 is formulated as a solution in 32% (w/v) 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Female Hartley guinea pigs are injected intraperitoneally with a 10 mg/mL solution of ST-193 at a volume of either 2.5 mL per kg of body weight (25 mg/kg) or 10 mL per kg (100 mg/kg). Four animals per dose are used, with blood samples collected from two animals per dose at each time point in alternating fashion. Blood samples are obtained at the indicated time points (4-24 h)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

ST-193 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4513 mL 12.2567 mL 24.5134 mL 61.2835 mL
5 mM 0.4903 mL 2.4513 mL 4.9027 mL 12.2567 mL
10 mM 0.2451 mL 1.2257 mL 2.4513 mL 6.1284 mL
15 mM 0.1634 mL 0.8171 mL 1.6342 mL 4.0856 mL
20 mM 0.1226 mL 0.6128 mL 1.2257 mL 3.0642 mL
25 mM 0.0981 mL 0.4903 mL 0.9805 mL 2.4513 mL
30 mM 0.0817 mL 0.4086 mL 0.8171 mL 2.0428 mL
40 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5321 mL
50 mM 0.0490 mL 0.2451 mL 0.4903 mL 1.2257 mL
60 mM 0.0409 mL 0.2043 mL 0.4086 mL 1.0214 mL
80 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7660 mL
100 mM 0.0245 mL 0.1226 mL 0.2451 mL 0.6128 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST-1932320274-72-2ST193ST 193ArenavirusInhibitorinhibitorinhibit

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产品名称：
ST-193 hydrochloride
目录号：
HY-101441A
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