2. Stem Cell/Wnt
  3. Smo
  4. Saridegib

Saridegib  (Synonyms: IPI-926; Patidegib)

目录号: HY-16587 纯度: 99.87%
COA 产品使用指南

摩尔计算器

Saridegib 是 Smo 的特异性有效抑制剂，这是 Hedgehog 通路中关键的跨膜信号蛋白。

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Saridegib Chemical Structure

Saridegib Chemical Structure

CAS No. : 1037210-93-7

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规格 价格 是否有货 数量
1 mg ￥5440
In-stock
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Customer Review

Other Forms of Saridegib:

Saridegib 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

IC50 & Target

Smo[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C3H 10T1/2 EC50
0.007 μM
Compound: 28
Inhibition of HedgeHog pathway in mouse C3H10T1/2 cells assessed as inhibition of 20-(S)-hydroxysterol/22-(S)-hydroxysterol-induced osteoblastic differentiation after 72 hrs by Gli-luc reporter assay
Inhibition of HedgeHog pathway in mouse C3H10T1/2 cells assessed as inhibition of 20-(S)-hydroxysterol/22-(S)-hydroxysterol-induced osteoblastic differentiation after 72 hrs by Gli-luc reporter assay
[PMID: 19522463]
体内研究
(In Vivo)

Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

504.77

Formula

C29H48N2O3S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.87%

COA (289 KB) LCMS (88 KB)

产品使用指南 (1538 KB)
参考文献

Saridegib 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Saridegib1037210-93-7IPI-926 PatidegibIPI926IPI 926SmoSmoothenedInhibitorinhibitorinhibit

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目录号：
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