2. Metabolic Enzyme/Protease
  3. MMP Endogenous Metabolite
  4. Stigmasterol

Stigmasterol  (Synonyms: 豆甾醇)

目录号: HY-N0131 纯度: ≥98.0%
COA 产品使用指南 技术支持

Stigmasterol (Stigmasterin) 是一种植物性甾醇，不仅具有降低胆固醇的活性，并且在风湿性疾病的研究中被评价为抗硬化因子。

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Stigmasterol Chemical Structure

Stigmasterol Chemical Structure

CAS No. : 83-48-7

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规格 价格 是否有货 数量
100 mg ￥500
In-stock
200 mg   询价  
500 mg   询价  

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Customer Review

Other Forms of Stigmasterol:

Stigmasterol 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

IC50 & Target

Human Endogenous Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
10.36 μM
Compound: SS
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 24 hrs by MTT assay
10.1039/C6MD00178E
A549 IC50
98.2 μM
Compound: 4, stigmasterol
Cytotoxicity against human A549 cells after 1 hr by MTT assay
Cytotoxicity against human A549 cells after 1 hr by MTT assay
[PMID: 18343122]
Calu-1 IC50
> 100 μM
Compound: 7
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Calu1 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
DU-145 IC50
22.73 μM
Compound: 3
Cytotoxicity against human DU145 cells after 24 hrs by MTT assay
Cytotoxicity against human DU145 cells after 24 hrs by MTT assay
[PMID: 22687747]
HeLa IC50
> 100 μM
Compound: 7
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human HeLa cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
HeLa IC50
> 50 μM
Compound: 3
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 19388709]
HeLa IC50
12.21 μM
Compound: SS
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 24 hrs by MTT assay
10.1039/C6MD00178E
J774 IC50
> 242.3 μM
Compound: 12
Cytotoxicity against mouse J774 cells by alamar blue assay
Cytotoxicity against mouse J774 cells by alamar blue assay
[PMID: 17637068]
K562 IC50
> 100 μM
Compound: 7
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human K562 cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
K562 IC50
11.14 μM
Compound: 3
Cytotoxicity against human K562 cells after 24 hrs by MTT assay
Cytotoxicity against human K562 cells after 24 hrs by MTT assay
[PMID: 22687747]
KB ED50
> 4 μg/mL
Compound: stigmasterol
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
[PMID: 9644061]
MCF7 IC50
21.43 μM
Compound: 3
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay
[PMID: 22687747]
MDA-MB-231 IC50
564 μM
Compound: 8
Cytotoxicity against human MDA-MB-231 cells after 3 days by Celltiter-Glo assay
Cytotoxicity against human MDA-MB-231 cells after 3 days by Celltiter-Glo assay
[PMID: 28945373]
P388D1 IC50
> 50 μM
Compound: 3
Cytotoxicity against mouse P388D1 cells by MTT assay
Cytotoxicity against mouse P388D1 cells by MTT assay
[PMID: 19388709]
PC-3 IC50
18.28 μM
Compound: 3
Cytotoxicity against human PC3 cells after 24 hrs by MTT assay
Cytotoxicity against human PC3 cells after 24 hrs by MTT assay
[PMID: 22687747]
Raji IC50
> 100 μM
Compound: 7
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human Raji cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
Vero IC50
> 100 μM
Compound: 7
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of african green monkey Vero cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
WISH IC50
> 100 μM
Compound: 7
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
Inhibition of human WISH cell proliferation assessed as [3H]thymidine incorporation after 3 days by scintillation counting
[PMID: 11374975]
体外研究
(In Vitro)

Stigmasterol 与 IL-1beta 处理的细胞预孵育显示人和小鼠中的 MMP-3 mRNA、小鼠中的 MMP-3 蛋白、小鼠和人中的 MMP-13 mRNA、人中的 ADAMTS-4 mRNA、人中的 PGE2 蛋白显著减少和鼠标。Stigmasterol 还能够抵消 IL-1beta 诱导的 NF-κB 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Stigmasterol 相关抗体:
分子量

412.69

Formula

C29H48O
CAS 号
性状

固体

颜色

White to off-white

中文名称

豆甾醇
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

Acetone 中的溶解度 : 2 mg/mL (4.85 mM; 超声助溶 (<60°C))

DMF 中的溶解度 : 1 mg/mL (2.42 mM; 超声助溶 (<60°C))

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

1M NaOH 中的溶解度 : < 1 mg/mL (insoluble)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4231 mL 12.1156 mL 24.2313 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： Corn Oil

    Solubility: 3.12 mg/mL (7.56 mM); 澄清溶液; 超声助溶 (<50°C)

  • 方案 二

    请依序添加每种溶剂： 15% Cremophor EL    85% Saline

    Solubility: 10 mg/mL (24.23 mM); 悬浊液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (287 KB) HNMR (253 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

A model of newborn mouse chondrocytes and human osteoarthritis (OA) chondrocytes are used in primary culture stimulated with or without IL-1β (10 ng/mL), for 18 h. Cells are pre-incubated with Stigmasterol (20 mg/mL) for 48 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Stigmasterol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF / Acetone 1 mM 2.4231 mL 12.1156 mL 24.2313 mL 60.5782 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stigmasterol83-48-7豆甾醇MMPEndogenous MetaboliteMatrix metalloproteinasesInhibitorinhibitorinhibit

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目录号：
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