2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. Synaptamide

Synaptamide  (Synonyms: N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide)

目录号: HY-100197 纯度: 99.30%
COA 产品使用指南

摩尔计算器

Synaptamide (Dehydroepiandrosteron; DHEA) 是一种内源性代谢物，是 Anandamide 的结构类似物。Synaptamide 与大麻素-1 和 2 (CB1 和 CB2) 大麻素受体结合并具有抗炎特性。Synaptamide 第一个粘附 G 蛋白偶联受体 (aGPCR) 的小分子内源性配体。

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Synaptamide Chemical Structure

Synaptamide Chemical Structure

CAS No. : 162758-94-3

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规格 价格 是否有货 数量
5 mg (67 mM * 200 μL in Ethanol) ￥700
In-stock
10 mg (67 mM * 400 μL in Ethanol) ￥1300
In-stock

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Customer Review

Synaptamide 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Cannabinoid Receptor 亚型特异性产品:

查看所有亚型
CB1 CB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR)[1] [2][3].

IC50 & Target[2]

CB1

633 nM (Ki)

CB2

3843 nM (Ki)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RBL-2H3 IC50
25 μM
Compound: 18; DHEA
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
[PMID: 31618024]
RBL-2H3 IC50
25 μM
Compound: 18; DHEA
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity incubated for 30 mins prior to CB2 antagonist AM630 addition further incubated for 30 mins followed by
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity incubated for 30 mins prior to CB2 antagonist AM630 addition further incubated for 30 mins followed by
[PMID: 31618024]
RBL-2H3 IC50
7.6 μM
Compound: 18; DHEA
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity incubated for 30 mins prior to FAAH inhibitor URB597 addition further incubated for 30 mins followed b
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity incubated for 30 mins prior to FAAH inhibitor URB597 addition further incubated for 30 mins followed b
[PMID: 31618024]
Sf9 IC50
> 50 μM
Compound: 18; DHEA
Inhibition of human FAAH expressed in baculovirus infected Sf9 cells using N-(6-methoxypyridin-3-yl)octanamide as substrate measured for 15 mins by fluorescence based assay
Inhibition of human FAAH expressed in baculovirus infected Sf9 cells using N-(6-methoxypyridin-3-yl)octanamide as substrate measured for 15 mins by fluorescence based assay
[PMID: 31618024]
体外研究
(In Vitro)

Synaptamide (Dehydroepiandrosteron; DHEA) is a weak agonist at both CB1 and CB2 receptors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Synaptamide 相关抗体:
体内研究
(In Vivo)

Synaptamide (10 mg/kg; subcutaneously; daily for 7 days) promotes cognitive recovery in rats subjected to mild traumatic brain injury (mTBI)[1].
Synaptamide (2-10 mg/kg; adult male C57BL/6J mice) reduced the levels of nociceptive and inflammatory pain-related behaviour over 60 min in the intraplantar formaldehyde assay via both intraperitoneal and local intraplantar administration[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats;260 ± 20 g, age 3 months; mTBI model)[1]
Dosage: 10 mg/kg
Administration: Subcutaneously; daily for 7 days
Result: Reversed the mTBI-induced cognitive deficits.
分子量

371.56

Formula

C24H37NO2
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
溶解性数据
细胞实验： 

Ethanol 中的溶解度 : 25 mg/mL (67.28 mM; 超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 10 mg/mL (26.91 mM); 澄清溶液

    此方案可获得 ≥ 10 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 100.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂： 10% EtOH    90% Corn Oil

    Solubility: ≥ 10 mg/mL (26.91 mM); 澄清溶液

    此方案可获得 ≥ 10 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

    以 1 mL 工作液为例，取 100 μL 100.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 玉米油中，混合均匀。

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.3%

COA (275 KB)

产品使用指南 (1538 KB)
参考文献

Synaptamide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.6914 mL 13.4568 mL 26.9136 mL 67.2839 mL
5 mM 0.5383 mL 2.6914 mL 5.3827 mL 13.4568 mL
10 mM 0.2691 mL 1.3457 mL 2.6914 mL 6.7284 mL
15 mM 0.1794 mL 0.8971 mL 1.7942 mL 4.4856 mL
20 mM 0.1346 mL 0.6728 mL 1.3457 mL 3.3642 mL
25 mM 0.1077 mL 0.5383 mL 1.0765 mL 2.6914 mL
30 mM 0.0897 mL 0.4486 mL 0.8971 mL 2.2428 mL
40 mM 0.0673 mL 0.3364 mL 0.6728 mL 1.6821 mL
50 mM 0.0538 mL 0.2691 mL 0.5383 mL 1.3457 mL
60 mM 0.0449 mL 0.2243 mL 0.4486 mL 1.1214 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Synaptamide162758-94-3N-Docosahexaenoyl ethanolamine (DHEA) Docosahexaenoyl ethanolamideCannabinoid ReceptorendogenousligandinflammatorynociceptiveInhibitorinhibitorinhibit

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