MicroRNA

miRNA

MicroRNAs (miRNAs) are a naturally occurring class of small (approximately 22 nucleotides long) non-coding RNAs that regulate post-transcriptional gene expression to control cellular processes, development, cell differentiation, and homeostasis. MicroRNAs are essential for embryo, cell, and tissue development, regulating cell differentiation, proliferation, and apoptosis, hence their importance in human reproduction. Meanwhile, abnormal expression or function of miRNAs are found to be closely associated with the occurrence or development of various human diseases, including cancers. In light of their significant roles in physiology and pathology, miRNAs are emerging as novel biomolecular targets for chemical-biological studies, including regulation and detection.

Multiple steps are involved in the generation of miRNAs. Most miRNAs are produced by the canonical biogenesis pathway, which involves transcription by RNA polymerase II to make a primary transcript (pri-miRNA) and cleavage by the microprocessor complex to yield a hairpin precursor miRNA (pre-miRNA) in the nucleus. The pre-miRNA is then exported into the cytoplasm, where cleavage by the enzyme Dicer creates a double-stranded RNA duplex. Only a single strand from the double-stranded RNA duplex forms the mature miRNA and is incorporated into the RNA-induced silencing complex (RISC), which guides the binding of Argonaute (AGO) proteins in the RISC to the 3’untranslated region (UTR) to either repress protein translation or promote mRNA degradation. In addition to canonical miRNA biogenesis pathways, non-canonical microprocessor-independent or Dicer-independent miRNA biogenesis pathways also exist. Despite miRNAs being mostly involved in the down-regulation of gene expression, there are reports of miRNAs promoting gene expression. In addition, relationships between miRNAs and their targets are not always one-to-one in a specific cell type. In fact, a single miRNA may regulate many mRNA targets, and conversely, a single mRNA target also can be regulated by many miRNAs.

MicroRNA 相关产品 (18472)
抗体 (1)

By Effects:	抑制剂 (24) 激动剂 (1) 拮抗剂 (2) 激活剂 (11) 调节剂 (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-19731

SID 3712249	Inhibitor	99.26%
SID 3712249 (MiR-544 Inhibitor 1) 是一种 miR-544 生物合成抑制剂。SID 3712249 直接与前体 miRNA 结合。SID 3712249 阻断成熟 microRNA 的产生并减少 miR-544、HIF-1α 和 ATM 转录物。SID 3712249 可用于癌症研究。

HY-RI00449A

hsa-miR-21-5p antagomir		98.06%
hsa-miR-21-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链，全链进行甲氧基修饰，在5'端和3'端分别有2个和4个硫代骨架修饰，并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能。相比于miRNA inhibitor，miRNA antagomir在动物实验中具有更高的稳定性和抑制效果，更易通过细胞膜、组织间隙而富集于靶细胞。

hsa-miR-21-5p antagomir hsa-miR-21-5p antagomir

HY-R04602A

MicroRNA Agomir Negative Control
MicroRNA Agomir Negative Control是一种经过特殊化学修饰的miRNA模拟物，可作为阴性对照使用。MicroRNA Agomir Negative Control 的序列是根据 cel-mir-239b的序列设计，这个序列是被广泛作为阴性对照使用。它与人类、小鼠和大鼠的miRNA具有最小的序列一致性。

MicroRNA Agomir Negative Control MicroRNA Agomir Negative Control

HY-R00497

hsa-miR-26b-5p mimic hsa-miR-26b-5p 模拟物		98.84%
hsa-miR-26b-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-26b-5p mimic hsa-miR-26b-5p mimic

HY-RI00497

hsa-miR-26b-5p inhibitor
hsa-miR-26b-5p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-26b-5p inhibitor hsa-miR-26b-5p inhibitor

HY-100692

Lin28-let-7a antagonist 1	Antagonist	99.48%
Lin28-let-7a antagonist 1 对 Lin28-let-7a 的结合有明显的拮抗作用，其对 Lin28A-let-7a-1 结合的 IC₅₀ 值为 4.03 μM。

HY-R00326

hsa-miR-17-5p mimic hsa-miR-17-5p 模拟物		98.29%
hsa-miR-17-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-17-5p mimic hsa-miR-17-5p mimic

HY-RI00138

hsa-miR-124-3p inhibitor
hsa-miR-124-3p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-124-3p inhibitor hsa-miR-124-3p inhibitor

HY-R00274

hsa-miR-141-3p mimic hsa-miR-141-3p 模拟物
hsa-miR-141-3p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-141-3p mimic hsa-miR-141-3p mimic

HY-R00248

hsa-miR-132-3p mimic hsa-miR-132-3p 模拟物
hsa-miR-132-3p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-132-3p mimic hsa-miR-132-3p mimic

HY-R00714

hsa-miR-34a-5p mimic hsa-miR-34a-5p 模拟物
hsa-miR-34a-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-34a-5p mimic hsa-miR-34a-5p mimic

HY-R00116

hsa-miR-122-5p mimic hsa-miR-122-5p 模拟物
hsa-miR-122-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-122-5p mimic hsa-miR-122-5p mimic

HY-RI04604A

mmu-miR-186-5p antagomir
mmu-miR-186-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链，全链进行甲氧基修饰，在5'端和3'端分别有2个和4个硫代骨架修饰，并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能。相比于miRNA inhibitor，miRNA antagomir在动物实验中具有更高的稳定性和抑制效果，更易通过细胞膜、组织间隙而富集于靶细胞。

mmu-miR-186-5p antagomir mmu-miR-186-5p antagomir

HY-R00282

hsa-miR-145-5p mimic hsa-miR-145-5p 模拟物
hsa-miR-145-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-145-5p mimic hsa-miR-145-5p mimic

HY-RI00480A

hsa-miR-23a-3p antagomir		98.87%
hsa-miR-23a-3p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链，全链进行甲氧基修饰，在5'端和3'端分别有2个和4个硫代骨架修饰，并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能。相比于miRNA inhibitor，miRNA antagomir在动物实验中具有更高的稳定性和抑制效果，更易通过细胞膜、组织间隙而富集于靶细胞。

hsa-miR-23a-3p antagomir hsa-miR-23a-3p antagomir

HY-115581A

Thymidine 3',5'-diphosphate tetrasodium	Inhibitor
Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium 是葡萄球菌核酸酶和含有 1 的都铎结构域 (SND1，MicroRNA 调控复合体 RISC 亚基) 与 [3,5-²H₂] 酪氨酸核酸酶 ( [3,5-²H₂] tyrosyl nuclease) 的选择性抑制剂。Thymidine 3',5'-diphosphate tetrasodium 具有抗肿瘤活性，在生化反应也可用作催化剂。

HY-R00495

hsa-miR-26a-5p mimic hsa-miR-26a-5p 模拟物
hsa-miR-26a-5p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-26a-5p mimic hsa-miR-26a-5p mimic

HY-RI00282

hsa-miR-145-5p inhibitor
hsa-miR-145-5p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA，阻止miRNA与其靶基因的互补配对，从而抑制miRNA的功能，可用于miRNA 功能缺失性（loss-of-function）研究。

hsa-miR-145-5p inhibitor hsa-miR-145-5p inhibitor

HY-R00500

hsa-miR-27b-3p mimic hsa-miR-27b-3p 模拟物
hsa-miR-27b-3p mimic 是一种化学合成的miRNA模拟物，能模拟内源性miRNA，上调miRNA活性，用于功能获得性(gain-of-function)研究。

hsa-miR-27b-3p mimic hsa-miR-27b-3p mimic

HY-R00449A

hsa-miR-21-5p agomir		98.45%
hsa-miR-21-5p agomir 是一种经过特殊化学修饰的miRNA模拟物，miRNA成熟链全链进行甲氧基修饰，在5'端和3'端分别有2个和4个硫代骨架修饰，并在3'端连接有高亲和性胆固醇修饰。miRNA agomir 可以模拟内源性miRNA，上调miRNA活性。与普通模拟物相比，miRNA agomir在动物实验中具有更高的稳定性和抑制效果，更易通过细胞膜、组织间隙而富集于靶细胞。

hsa-miR-21-5p agomir hsa-miR-21-5p agomir

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