SULT (磺基转移酶 (SULT) )

Sulfotransferase is a transferase enzyme that catalyzes the transfer the sulfate groups, and participates in the metabolism of endogenous compounds (such as hormones, neurotransmitters) and exogenous compounds (such as drugs, environmental pollutants). Sulfotransferase is mainly located in cytoplasm and in the Golgi apparatus, which contributes to the sulfation of small molecule substrates (such as drugs, hormones, neurotransmitters) and the sulfation of macromolecules (such as peptides, proteins, lipids, and glycosaminoglycans), respectively. Sulfotransferase have been identified into multiple subfamilies, mainly including SULT1, SULT2, and SULT4. Sulfotransferase dysfunction would lead to abnormal drug metabolism, cancer, endocrine diseases and neurological diseases^[1][2].