Emopamil Binding Protein

Emopamil Binding Protein (EBP) is a membrane-bound cholesterol biosynthetic enzyme involved in the key steps of cholesterol synthesis and a target for neuroprotective agents. It belongs to the extended EBP superfamily. Emopamil Binding Protein is mainly localized in the endoplasmic reticulum membrane and widely expressed in various tissues, especially the liver. EBP can bind to chemotherapeutic drugs, reducing their effectiveness and leading to tumor resistance.

参考文献:

[1]. Emopamil. Pharmacology, Toxicology and Pharmaceutical Science. Sciencedirect.

[2]. Silve S, et al. Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast. J Biol Chem. 1996 Sep 13;271(37):22434-40. [Content Brief]

[3]. Reardon D A, et al. DSP-0390, an oral emopamil binding protein (EBP) inhibitor, in patients with recurrent high-grade glioma: A first-in-human, phase 1 study[J]. 2022.

Emopamil Binding Protein抑制剂 (1)

Emopamil Binding Protein 相关产品 (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-162351

EBP-IN-1	Inhibitor	99.67%
EBP-IN-1 (compound 11) 是 emopamil 结合蛋白 (EBP) 的抑制剂，而 EBP 是胆固醇生物合成途径中的一种甾醇异构酶。EBP-IN-1 在啮齿类动物中的半衰期较长，具有良好的代谢周转和脑渗透特性。EBP-IN-1 增强了人类皮质类器官中少突胶质细胞的形成。

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