PEPCK (磷酸烯醇丙酮酸羧激酶)

PEPCK (Phosphoenolpyruvate carboxykinase) is an enzyme in the lyase family used in four pathways: gluconeogenesis, glyceroneogenesis, the synthesis of serine, and the conversion of the carbon skeletons of amino acids. PEPCK is the rate-limiting enzyme of gluconeogenesis in the liver and kidney, and is also a key regulator of TCA cycle flux. PEPCK can catalyze oxaloacetate into phosphoenolpyruvate (PEP) and carbon dioxide. PEPCK has two isoforms: PEPCK1 (PEPCK-C) and PEPCK2 (PEPCK-M). PEPCK1/PEPCK2 is distributed in the cytosol and mitochondria, and is overexpressed in many cancers^[1][2].