2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PI4P5K

PI4P5K 

Phosphatidylinositol 4-phosphate 5-kinases

Phosphatidylinositol 4-phosphate 5-kinases (PI4P5K) are a class of enzymes that phosphorylate phosphatidylinositol 4-phosphate. Phosphatidylinositol 4-phosphate 5-kinases phosphorylate phosphatidylinositol 4-phosphate (PI4P) in the 5-position to form phosphatidylinositol 4,5-bisphosphate (PI45P2). There are two types of phosphatidylinositol 4-phosphate 5-kinases found which includes Type I and Type II. Murine PI4P5K type Ibeta (mPIP5K-Ibeta) was implicated in receptor mediated endocytosis through the isolation of a truncated and inactive form of the enzyme that blocked the ligand-dependent downregulation of the colony-stimulating factor-1 receptor. Phosphatidylinositol 4-phosphate 5-kinases regulate diverse cellular processes such as G protein-coupled receptor(GPCR) signaling, vesicle trafficking, chemotaxis and cellular movement[1][2].

PI4P5K 相关产品 (4):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16937
    ISA-2011B Inhibitor 99.85%
    ISA-2011B是PIP5K1α的抑制剂， 具有抗癌活性。
    ISA-2011B
  • HY-163572
    PIP5K1α-IN-1 Inhibitor
    PIP5K1α-IN-1 (Compound 3e) 是一种磷脂酰肌醇 4-磷酸 5-激酶 I 型 α (PIP5K1α) 抑制剂，IC50 为 0.46 μM。
    PIP5K1α-IN-1
  • HY-163476
    PIP5K1C-IN-1 Inhibitor
    PIP5K1C-IN-1 (Compound 30) 是一种有效的 PIP5K1C 抑制剂，IC50 为 0.80 nM。PIP5K1C-IN-1 在小鼠中表现出较低的总清除率和较高水平的激酶选择性。PIP5K1C-IN-1 可用于癌症和慢性疼痛的研究。
    PIP5K1C-IN-1
  • HY-163477
    PIP5K1C-IN-2 Inhibitor
    PIP5K1C-IN-2 (compound 33) 是一种有效的选择性 4-磷酸 5-激酶 1 C (PIP5K1C) 抑制剂，IC50 值 0.0059 µM。
    PIP5K1C-IN-2
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