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  3. Antibiotic
  4. Thimerosal

Thimerosal  (Synonyms: 硫柳汞; Sodium ethylmercurithiosalicylate)

目录号: HY-19588 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Thimerosal 是一种含汞疫苗防腐剂，也是神经发育障碍病因中的一个可疑因素。

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Thimerosal Chemical Structure

Thimerosal Chemical Structure

CAS No. : 54-64-8

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规格 价格 是否有货 数量
50 mg ￥550
In-stock
100 mg ￥830
In-stock
500 mg ￥1250
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Thimerosal 相关抗体

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thimerosal, a mercury-containing vaccine preservative, is a suspected factor in the etiology of neurodevelopmental disorders.

体内研究
(In Vivo)

The Thimerosal (THIM) administration increases μ-opioid receptors (MORs) density in the periaqueductal gray (PAG) in a dose-dependent manner. Treatment with higher doses of Thimerosal statistically significantly increases MOR density in the dorsomedial periaqueductal gray (DMPAG) and lateral periaqueductal gray (LPAG) regions. At the dose 3,000 μg Hg/kg, Thimerosal also augments MOR density in the caudate putamen (CPU). In contrast, the administration of Thimerosal at both higher doses decreases MOR density in the dentate gyrus (DG)[1]. Thimerosal administration (4 injections, i.m., 240 μg Hg/kg on postnatal days 7, 9, 11, 15) induces lasting changes in amino acid overflow: an increase of glutamate and aspartate accompanied by a decrease of glycine and alanine; measured 10 to 14 weeks after the injections. Four injections of Thimerosal at a dose of 12.5 μg Hg/kg do not alter glutamate and aspartate concentrations at microdialysis time. Application of Thimerosal to the prefrontal cortex (PFC) in perfusion fluid evokes a rapid increase of glutamate overflow. Coadministration of the neurosteroid, dehydroepiandrosterone sulfate (DHEAS; 80 mg/kg; i.p.) prevents the Thimerosal effect on glutamate and aspartate; the steroid alone has no influence on these amino acids. Coapplication of dehydroepiandrosterone sulfate (DHEAS) with Thimerosal in perfusion fluid also blocks the acute action of Thimerosal on glutamate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

404.81

Formula

C9H9HgNaO2S
CAS 号
性状

固体

颜色

White to off-white

中文名称

硫柳汞；硫汞撒
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (247.03 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4703 mL 12.3515 mL 24.7029 mL
5 mM 0.4941 mL 2.4703 mL 4.9406 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (288 KB) HNMR (189 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1]

Male rats are used in this study. On the 20th postnatal week, the animals are euthanized by pentobarbital overdosing, and then decapitated. The rats treated with two higher doses of Thimerosal (THIM) (1,440 and 3,000 μg Hg/kg) are from the original litters, which are used for different behavioral and pathological tests, but are experimentally naïve. A separate group of experimentally naïve rats, treated with two lower doses of Thimerosal, 12 and 240 μg Hg/kg (4 litters per each drug-treatment) is sacrificed on the 8th postnatal week according to the same procedure. Each experimental group is composed of 5 animals, with 2 at the most coming from the same litter[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Thimerosal 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4703 mL 12.3515 mL 24.7029 mL 61.7574 mL
5 mM 0.4941 mL 2.4703 mL 4.9406 mL 12.3515 mL
10 mM 0.2470 mL 1.2351 mL 2.4703 mL 6.1757 mL
15 mM 0.1647 mL 0.8234 mL 1.6469 mL 4.1172 mL
20 mM 0.1235 mL 0.6176 mL 1.2351 mL 3.0879 mL
25 mM 0.0988 mL 0.4941 mL 0.9881 mL 2.4703 mL
30 mM 0.0823 mL 0.4117 mL 0.8234 mL 2.0586 mL
40 mM 0.0618 mL 0.3088 mL 0.6176 mL 1.5439 mL
50 mM 0.0494 mL 0.2470 mL 0.4941 mL 1.2351 mL
60 mM 0.0412 mL 0.2059 mL 0.4117 mL 1.0293 mL
80 mM 0.0309 mL 0.1544 mL 0.3088 mL 0.7720 mL
100 mM 0.0247 mL 0.1235 mL 0.2470 mL 0.6176 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thimerosal54-64-8Sodium ethylmercurithiosalicylate硫柳汞硫汞撒AntibioticInhibitorinhibitorinhibit

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