2. 诱导疾病模型产品 NF-κB Immunology/Inflammation Metabolic Enzyme/Protease
  3. 心血管系统疾病模型 Reactive Oxygen Species Endogenous Metabolite
  4. 高血压模型
  5. Uric acid

Uric acid  (Synonyms: 尿酸)

目录号: HY-B2130 纯度: 99.96%
COA 产品使用指南

摩尔计算器

Uric acid 是氧自由基 (oxygen radical) 的清除剂，是一种非常重要的抗氧化剂，有助于维持血压的稳定和抗氧化应激。Uric acid 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。

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Uric acid Chemical Structure

Uric acid Chemical Structure

CAS No. : 69-93-2

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规格 价格 是否有货 数量
500 mg ￥400
In-stock
1 g ￥500
In-stock
5 g   询价  
10 g   询价  

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Customer Review

Other Forms of Uric acid:

Uric acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.3 mM
Compound: 1175
Substrate uptake by the Glucose Transporter Type 9 (GLUT9, SLC2A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC2A9 isoform 1
Substrate uptake by the Glucose Transporter Type 9 (GLUT9, SLC2A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC2A9 isoform 1
10.5281/zenodo.7360607
体外研究
(In Vitro)

Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Uric acid 相关抗体:
体内研究
(In Vivo)

Uric acid (250 mg/kg; p.o.) ameliorates indomethacin-induced enteropathy[2].
Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57BL/6J mice[2]
Dosage: 250 mg/kg body weight
Administration: P.o.
Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
Clinical Trial
分子量

168.11

Formula

C5H4N4O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

尿酸
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

1M NaOH 中的溶解度 : 8.33 mg/mL (49.55 mM; ultrasonic and warming and adjust pH to 12 with 1M NaOH and heat to 60°C)

H2O 中的溶解度 : 6.25 mg/mL (37.18 mM; ultrasonic and adjust pH to 10 with 1M NaOH)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.9485 mL 29.7424 mL 59.4849 mL
5 mM 1.1897 mL 5.9485 mL 11.8970 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： 0.5% CMC-Na/saline water

    Solubility: 10 mg/mL (59.48 mM); 悬浊液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.96%

COA (286 KB) HNMR (263 KB) RP-HPLC (185 KB) MS (68 KB)

产品使用指南 (1538 KB)
参考文献

Uric acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / 1M NaOH 1 mM 5.9485 mL 29.7424 mL 59.4849 mL 148.7122 mL
5 mM 1.1897 mL 5.9485 mL 11.8970 mL 29.7424 mL
10 mM 0.5948 mL 2.9742 mL 5.9485 mL 14.8712 mL
15 mM 0.3966 mL 1.9828 mL 3.9657 mL 9.9141 mL
20 mM 0.2974 mL 1.4871 mL 2.9742 mL 7.4356 mL
25 mM 0.2379 mL 1.1897 mL 2.3794 mL 5.9485 mL
30 mM 0.1983 mL 0.9914 mL 1.9828 mL 4.9571 mL
1M NaOH 40 mM 0.1487 mL 0.7436 mL 1.4871 mL 3.7178 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uric acid69-93-2尿酸Reactive Oxygen SpeciesEndogenous Metabolitesingletoxygenperoxynitritelipidperoxidationantioxidantenteropathy oxidativestresscytotoxicityInhibitorinhibitorinhibit

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