2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Win-62005

Win-62005是一种环状AMP磷酸二酯酶III (PDE III) 抑制剂，对于大鼠心脏和犬主动脉的 Ki 值分别为25和26 nM。

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Win-62005 Chemical Structure

Win-62005 Chemical Structure

CAS No. : 152633-54-0

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Win-62005 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.

IC50 & Target

Ki: 25 nM (PDE III), 25 nM (PDE III)[1]
体外研究
(In Vitro)

Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Win-62005 相关抗体:
体内研究
(In Vivo)

After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

226.23

Formula

C12H10N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Win-62005 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Win-62005152633-54-0Win62005Win 62005Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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产品名称：
Win-62005
目录号：
HY-U00136
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