2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. ZSET-845

ZSET-845是一种认知增强剂，可增强大鼠海马胆碱乙酰转移酶 (choline acetyltransferase) 活性。

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ZSET-845 Chemical Structure

ZSET-845 Chemical Structure

CAS No. : 324077-62-5

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ZSET-845 相关抗体

Top Publications Citing Use of Products

查看 Acyltransferase 亚型特异性产品:

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ACAT1 ACAT2 MGAT2 ACAT

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZSET-845 is a cognitive enhancer which enhances choline acetyltransferase activity in the hippocampus in the rat.

IC50 & Target

Choline acetyltransferase[1]
体外研究
(In Vitro)

ZSET-845 has no inhibitory action on AChE activity and enhances choline acetyltransferase (ChAT) activity in NB-1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ZSET-845 相关抗体:
体内研究
(In Vivo)

Treatment with ZSET-845 at the dose of 0.01, 0.1 and 1 mg/kg significantly ameliorates impaired performance caused by scopolamine. Oral administration of ZSET-845 causes an increase in ChAT activity in the hippocampus. In the hippocampus, ZSET-845 (0.01, 0.1 or 1 mg/kg) significantly increases ChAT activity (112%, 113.8% or 108.7%, respectively) compared with matched vehicle-injected control rats[1]. Oral administration of ZSET845 at a dose of 1 or 10 mg/kg ameliorates learning impairment in passive avoidance task and enhanced ChAT activity in the basal forebrain, medial septum and hippocampus, and increases in the number of ChAT-immunoreactive cells in the medial septum in Ab-treated rats to the levels of vehicle-injected control rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

314.38

Formula

C21H18N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Rats: The passive avoidance apparatus consists of a small illuminated chamber and a larger dark chamber. The two chambers are separated by a guillotine door. On the first and second days of testing, each rat is placed in the apparatus and left for 3 min to habituate to the apparatus. On the third day, an acquisition trial is performed. Oral administration of ZSET-845 (0.001, 0.01, 0.1 or 1 mg/kg), donepezil or tacrine (0.01, 0.1, 1 or 10 mg/kg) is given 60 min before the acquisition trial. Scopolamine (2 mg/kg) is intraperitoneally (i.p.) injected 20 min before the acquisition trial. Matched control rats received vehicle only[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

ZSET-845 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZSET-845324077-62-5ZSET845ZSET 845AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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目录号：
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