2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. A-317920

A-317920 是一种选择性强效大鼠组胺 H3 受体 (H3R) 拮抗剂，全长大鼠和全长人类 H3R 的 pKi 值分别为 9.2 和 7.0。A-317920 对大鼠的选择性亲和力比人类 H3R 高 130 倍以上。A-317920 通过 H3R 阻断增强认知能力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

A-317920 Chemical Structure

A-317920 Chemical Structure

CAS No. : 360551-59-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

A-317920 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

查看所有亚型
H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A-317920 is a selective and potent rat histamine H3 receptor (H3R) antagonist with pKi value of 9.2 and 7.0 for full-length rat and full-length human H3R, respectively. A-317920 exhibits over 130 fold selective affinity for the rat over the human H3R. A-317920 enhances cognition via H3R blockade[1].

IC50 & Target[1]

rat H3 receptor

9.2 (pKi)

human H3 receptor

7.0 (pKi)

体外研究
(In Vitro)

A-317920 是大鼠 H3R 的强效拮抗剂，可逆转 R-α-甲基组胺 [(R)-α-MeHA] 对福斯可林刺激的 cAMP 形成 (pKb 值为 9.1) 的抑制，但在共表达 Galphaqi5-蛋白 的细胞中的环化酶 (pKb 值为 6.3) 和钙动员 (pKb 值为 7.3) 测定中，它对人类 H3R 是一种弱拮抗剂[1]。
A-317920 可有效拮抗天然 H3R，方法是阻断组胺抑制大鼠大脑皮层突触体钾诱发的 [3H] 组胺释放（pKb 值为 9.3）和 (R)-α-MeHA 逆转电场刺激的豚鼠回肠收缩（pA2 值为 8.3）[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

A-317920 相关抗体:
体内研究
(In Vivo)

A-317920（3-10 mg/kg；皮下注射；训练前 30 分钟；共进行五次试验）显著提高了自发性高血压大鼠 (SHR) 幼崽的回避测试[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive rat (SHR) pups (postnatal day 20–24) were trained to avoid a mild footshock[1]
Dosage: 3 mg/kg,10 mg/kg
Administration: s.c; 30 min prior to training; for a total of five trials
Result: Significantly improved in the avoidance test when compared with saline controls.
分子量

453.53

Formula

C25H31N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A-317920 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-317920360551-59-3A317920A 317920Histamine Receptorrat histamine H3 receptor antagonistenhances cognitionInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
A-317920
目录号：
HY-122171
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z