2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. A-425619

A-425619  (Synonyms: 化合物A 425619)

目录号: HY-110292
产品使用指南

摩尔计算器

A-425619 是一种有效的选择性 TRPV1 受体拮抗剂，可有效缓解急性和慢性炎症性疼痛和术后疼痛。

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A-425619 Chemical Structure

A-425619 Chemical Structure

CAS No. : 581809-67-8

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规格 价格 是否有货 数量
1 mg ￥2205
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

A-425619 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

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TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A-425619, a potent and selective TRPV1 receptor antagonist, is effective in alleviating acute and chronic inflammatory pain and postoperative pain[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
2 nM
Compound: 7
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as blockade of acid-induced receptor activation by FLIPR assay
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as blockade of acid-induced receptor activation by FLIPR assay
[PMID: 17489570]
HEK293 IC50
5 nM
Compound: 7
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as blockade of capsaicin-induced receptor activation by FLIPR assay
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as blockade of capsaicin-induced receptor activation by FLIPR assay
[PMID: 17489570]
HEK293 IC50
9 nM
Compound: 7
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as blockade of capsaicin-induced receptor activation by FLIPR assay
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as blockade of capsaicin-induced receptor activation by FLIPR assay
[PMID: 17489570]
体内研究
(In Vivo)

A-425619 (i.p., 100 μmoL/kg) 可以恢复弗氏完全佐剂（CFA；10 mg/mL）诱导的膝关节炎症引起的 C57BL/6J 小鼠自发挖掘行为的减少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

345.32

Formula

C18H14F3N3O
CAS 号
中文名称

化合物A 425619
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A-425619 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-425619581809-67-8化合物A 425619A425619A 425619TRP ChannelTransient receptor potential channelsTRPV1chronic inflammatorypostoperative painInhibitorinhibitorinhibit

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目录号：
HY-110292
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