2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. A-943931

A-943931 是一种有效的选择性组胺 H4 受体拮抗剂，对人和大鼠 H4R 的 Ki 值分别为 4.6、3.8 nM。A-943931 具有抗炎和抗伤害作用。

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A-943931 Chemical Structure

A-943931 Chemical Structure

CAS No. : 1027330-97-7

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A-943931 相关抗体

Top Publications Citing Use of Products

查看 Histamine Receptor 亚型特异性产品:

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A-943931 is a potent and selective histamine H4 receptor (H4R) antagonist with pKi values of 4.6, 3.8 nM for human and rat H4R, respectively. A-943931 shows anti-inflammatory and antinociceptive efficacy[1][2].

IC50 & Target[1]

Human H4 Receptor

4.6 nM (Ki)

Rat H4 receptor

3.8 nM (Ki)

体内研究
(In Vivo)

A-943931 在酵母聚糖诱导的小鼠腹膜炎中表现出抗炎活性，皮下注射和腹腔注射的ED50 值分别为 34, 33 µmol/kg[2]。
A-943931 (10, 30, 100 µmol/kg; 腹腔注射) 在大鼠的炎症性疼痛和神经性疼痛模型中表现出镇痛效果[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (carrageenan-induced inflammatory pain and spinal nerve ligation model of neuropathic pain)[2]
Dosage: 10, 30, 100 µmol/kg
Administration: I.p.
Result: Showed antinociceptive efficacy in an inflammatory pain model in rat at an ED50 value of 72 µmol/kg, ip, and in a neuropathic pain model at an ED50 value of 100 µmol/kg, ip.
分子量

295.38

Formula

C17H21N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

A-943931 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-9439311027330-97-7A943931A 943931Histamine Receptoranti-inflammatoryantinociceptivezymosanInhibitorinhibitorinhibit

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产品名称：
A-943931
目录号：
HY-113936
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