2. Neuronal Signaling
  3. AAK1
  4. AAK1-IN-3 TFA

AAK1-IN-3 TFA 是一种喹啉类似物，一种可透过血脑屏障的适配蛋白 2 相关激酶 1 (AAK1) 抑制剂，IC50 为 11 nM。AAK1-IN-3 具有用于神经病理性疼痛研究的潜力。

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AAK1-IN-3 TFA Chemical Structure

AAK1-IN-3 TFA Chemical Structure

CAS No. : 2761587-27-1

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AAK1-IN-3 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AAK1-IN-3 TFA, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC50 of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research[1].

体外研究
(In Vitro)

AAK1-IN-3 (compound (R)-31) TFA is brain-penetrant kinase inhibitors with a B/P ratio of 1.3[1].
AAK1-IN-3 TFA inhibits AAK1 in HEK293 cells (IC50=108 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AAK1-IN-3 TFA 相关抗体:
体内研究
(In Vivo)

AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) TFA causes a 46% reduction of μ2 phosphorylation in C57BL6 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

544.45

Formula

C24H22F6N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AAK1-IN-3 TFA 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AAK1-IN-32761587-27-1AAK1Adaptor-associated Kinase 1AP2-associated kinase 1quinoline analoguebrain-penetrantadaptor protein 2-associated kinase 1neuropathic painInhibitorinhibitorinhibit

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