2. Neuronal Signaling
  3. Sigma Receptor
  4. AB10

AB10 是选择性 S1R 拮抗剂。AB10 对 S1R 和 S2R 的 Ki 分别为 10 和 165 nM。AB10 能够逆转Capsaicin (HY-10448) 对模型造成的疼痛影响。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AB10 Chemical Structure

AB10 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AB10 相关抗体

Top Publications Citing Use of Products

查看 Sigma Receptor 亚型特异性产品:

查看所有亚型
Sigma 1 Receptor Sigma 2 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AB10 is a selective S1R antagonist. AB10 with Ki of 10, 165 nM for S1R and S2R, respectively. AB10 reverses the effect of Capsaicin (HY-10448) caused pain in model[1].

IC50 & Target[1]

Sigma 1 Receptor

10 nM (Ki)

Sigma 2 Receptor

165 nM (Ki)

体内研究
(In Vivo)

AB10 （20mg/kg，s.c.，在注射辣椒素前30分钟给药） 诱发S1R拮抗剂效应逆转疼痛，并表现出比 BD-1063 （HY-18101A） 更高的效力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Capsaicin-induced as a pain model in CD1 mice[1]
Dosage: 20 mg/kg
Administration: subcutaneous injection performed in different areas of the interscapular zone, administered 30 min before the injection of Capsaicin (HY-10448).
Result: Achieved similar effects at half the concentration of BD-1063 (HY-18101A) (40mg/kg).
Showed complete reversal of the mechanical hypersensitivity reaction.
分子量

334.50

Formula

C23H30N2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AB10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB10AB 10AB-10Sigma ReceptorS1R antagonistCapsaicin-induced mechanical hypersensitivity.Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AB10
目录号：
HY-149855
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z