1. Signaling Pathways
  2. Neuronal Signaling
  3. Sigma Receptor
  4. Sigma Receptor Inhibitors

Sigma Receptor Inhibitors

Sigma 1 Receptor

Sigma 2 Receptor

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Please try each isoform separately.

Sigma Receptor Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name Sigma 1 Receptor Sigma 2 Receptor Purity
BD-1047 dihydrobromide
Sigma 1 Receptor
  98.14%
PRE-084 hydrochloride
Sigma 1 Receptor
  99.92%
Cutamesine dihydrochloride
Sigma 1 Receptor
  98.01%
(±)-Vesamicol hydrochloride
Sigma 1 Receptor
Sigma 2 Receptor
99.81%
CM764
Sigma 1 Receptor, Ki: 86.6 nM
Sigma 2 Receptor, Ki: 3.5 nM
Dimemorfan phosphate
Sigma 1 Receptor
  99.87%
CT1812  
Sigma 2 Receptor
Blarcamesine hydrochloride
Sigma 1 Receptor
  99.87%
S1RA hydrochloride
Sigma 1 Receptor
  99.94%
Glycerol phenylbutyrate  
Sigma 2 Receptor
99.81%
PB28 dihydrochloride
Sigma 1 Receptor
Sigma 2 Receptor
99.97%
BD1063 dhydrochloride
Sigma 1 Receptor
  ≥98.0%
σ1 Receptor antagonist-1
Sigma 1 Receptor
  99.70%
S1RA
human σ1R, Ki: 17 nM
guinea pig σ1R, Ki: 23.5 nM
guinea pig σ2R, Ki: >1000 nM
rat σ2R, Ki: 9300 nM
99.43%
SKF 83959
Sigma 1 Receptor
  98.94%
Ditolylguanidine
Sigma 1 Receptor
Sigma 2 Receptor
99.66%
Pentoxyverine citrate
σ1, Ki: 41 nM
σ2, Ki: 894 nM
99.63%
Pentoxyverine
σ1, Ki: 41 nM
σ2, Ki: 894 nM
98.91%
PD 144418
Sigma 1 Receptor
  98.32%
Blarcamesine
Sigma 1 Receptor
  99.51%
S1R agonist 2
Sigma 1 Receptor, Ki: 1.1 nM
Sigma 2 Receptor, Ki: 88 nM
≥98.0%
Sigma-1 receptor antagonist 1
Sigma 1 Receptor
  98.64%
Sigma-1 receptor antagonist 2
Sigma 1 Receptor
  99.14%
BMY 14802
Sigma 1 Receptor
  98.96%
Sigma-1 receptor antagonist 3
Sigma 1 Receptor
  99.47%
Cutamesine
Sigma 1 Receptor
 
AD186
Sigma 1 Receptor, Ki: 2.7 nM
Sigma 2 Receptor, Ki: 27 nM
AB10
Sigma 1 Receptor, Ki: 10 nM
Sigma 2 Receptor, Ki: 165 nM
SUN-1334H free base
σ1, IC50: 5.46 μM
 
EST64454
σ1R, Ki: 22 nM
 
SW116 free base
Sigma 1 Receptor, Ki: 1055 nM
Sigma 2 Receptor, Ki: 14 nM
AB21
Sigma 1 Receptor, Ki: 13 nM
Sigma 2 Receptor, Ki: 102 nM
σ1 Receptor ligand 1
σ1, Ki: 3.9 nM
 
CB-64D
Sigma 1 Receptor, Ki: 3063 nM
Sigma 2 Receptor, Ki: 16.5 nM
Phenyltoloxamine
Sigma 1 Receptor, Ki: 160 nM
 
S1R agonist 1
Sigma 1 Receptor, Ki: 0.93 nM
Sigma 2 Receptor, Ki: 72 nM
≥98.0%
UMB24
σ1, Ki: 322 nM
σ2, Ki: 170 nM
KSCM-1
Sigma 1 Receptor, Ki: 27.5 nM
Sigma 2 Receptor, Ki: 528 nM
σ1 Receptor antagonist 4
σ1R, Ki: 10 nM
σ2, Ki: 370 nM