1. Neuronal Signaling
  2. Sigma Receptor
  3. UMB24

UMB24 是 σ2 受体 (σ2 receptor) 的有效拮抗剂,对 σ2 受体 (σ2 receptor) 和 σ1 受体的 Ki 分别为 170 nM 和 322 nM。UMB24 可减轻可卡因引起的抽搐和运动活动,但不会导致死亡。

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UMB24 Chemical Structure

UMB24 Chemical Structure

CAS No. : 1033-69-8

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查看 Sigma Receptor 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UMB24 is a potent antagonist of σ2 receptor, with the Ki of 170 nM anf 322 nM for σ2 receptor and σ1 receptor, respectively. UMB24 attenuats cocaine-induced convulsions and locomotor activity, but not lethality[1].

IC50 & Target[1]

σ2

170 nM (Ki)

σ1

322 nM (Ki)

分子量

267.37

Formula

C17H21N3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
UMB24
目录号:
HY-14222
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