2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. ABT-102

ABT-102 是一种有效且高度选择性的 Vanilloid Receptor (TRPV1) 受体拮抗剂。ABT-102 有效且可逆地增加热痛阈值并减少阈上口腔/皮肤热痛。ABT-102 可减少炎症、骨癌、术后和骨关节炎疼痛模型中动物的伤害性反应。

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ABT-102 Chemical Structure

ABT-102 Chemical Structure

CAS No. : 808756-71-0

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规格 价格 是否有货 数量
1 mg ￥2210
1 - 2 周
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of ABT-102:

ABT-102 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain[1][2].

IC50 & Target

TRPV1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
4 nM
Compound: 1, ABT-102
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay
Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assay
[PMID: 25100568]
分子量

348.44

Formula

C21H24N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ABT-102 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-102808756-71-0ABT102ABT 102TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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产品名称：
ABT-102
目录号：
HY-10635
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