2. GPCR/G Protein
  3. Neuropeptide FF Receptor
  4. AC-099

AC-099 hydrochloride (化合物 3) 是一种选择性的 NPFF2R 完全激动剂 (EC50=1189 nM)，也是 NPFF1R 部分激动剂 (EC50=2370 nM)。AC-099 hydrochloride 能减弱脊神经结扎诱导的大鼠超敏性。

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AC-099 Chemical Structure

AC-099 Chemical Structure

CAS No. : 849459-88-7

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规格 是否有货
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AC-099 的其他形式现货产品:

Other Forms of AC-099:

AC-099 相关抗体

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NPFFR1 NPFFR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats[1][2].

IC50 & Target

NPFF2R/1R[1][2].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
COS-1 EC50
1189 nM
Compound: AC-099
Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
[PMID: 22708927]
COS-1 EC50
2370 nM
Compound: AC-099
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
[PMID: 22708927]
体内研究
(In Vivo)

AC-099 (化合物 3; 30 mg/kg; i.p.; single) 完全减弱了 SNL (脊神经结扎) 诱导的大鼠超敏性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

264.63

Formula

C9H8ClF3N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AC-099 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-099849459-88-7AC099AC 099Neuropeptide FF ReceptorhypersensitivitySNLNPFFspinal nerve ligationInhibitorinhibitorinhibit

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产品名称：
AC-099
目录号：
HY-154829
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