AC-42 hydrochloride

目录号: HY-118806A: FAQs
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AC-42 hydrochloride 是 AC-42 (HY-118806) 的盐酸盐形式。AC-42 hydrochloride 是毒蕈碱 M1 受体 (muscarinic M1 receptor) 的变构激动剂，对人类野生型和 Y381A 突变型 M1 受体的 EC₅₀ 分别为 805 nM 和 220 nM。AC-42 hydrochloride 可刺激 CHO 细胞中的肌醇磷酸酯 (IP) 积累和钙动员。

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AC-42 hydrochloride Chemical Structure

CAS No. : 447407-36-5

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Other Forms of AC-42 hydrochloride:

AC-42 询价

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生物活性
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参考文献

生物活性

AC-42 hydrochloride is the hydrochloride salt form of AC-42 (HY-118806). AC-42 hydrochloride is an allosteric agonist for muscarinic M1 receptor with EC₅₀s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 hydrochloride stimulates the inositol phosphate (IP)-accumulation and calcium mobilization in CHO cells^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.21 μM Compound: AC-42	Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay Partial agonist activity at EGFP-fused human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay	[PMID: 22329602]
HEK293	EC₅₀	0.45 μM Compound: AC-42	Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay	[PMID: 22329602]
HEK293	EC₅₀	0.72 μM Compound: AC-42	Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay Partial agonist activity at EGFP-fused human M1 receptor N-terminal truncated at 11 residues expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay	[PMID: 22329602]
HEK293	EC₅₀	0.74 μM Compound: AC-42	Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay Partial agonist activity at human full length M1 receptor expressed in HEK293 cells assessed as induction of calcium response by fluorescence assay	[PMID: 22329602]

分子量

337.93

Formula

C₂₀H₃₂ClNO

CAS 号

447407-36-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78(4):648-57. [Content Brief]

[2]. Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69(1):236-46. [Content Brief]

AC-42 hydrochloride 相关分类

Neurological Disease

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-42447407-36-5AC42AC 42mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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AC-42 hydrochloride

Other Forms of AC-42 hydrochloride:

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AC-42 hydrochloride

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