2. Metabolic Enzyme/Protease
  3. Acetyl-CoA Carboxylase
  4. ACC1/2-IN-2

ACC1/2-IN-2 (compound PF-3) 是一种有效的 ACC1/2 抑制剂。ACC1 和 ACC2的 IC50 值分别为 22 和 48 nM。 ACC1/2-IN-2 具有抗增殖活性，可用于癌症研究。

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ACC1/2-IN-2 Chemical Structure

ACC1/2-IN-2 Chemical Structure

CAS No. : 1031411-94-5

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ACC1/2-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ACC1/2-IN-2 (compound PF-3) is a potent ACC1/2 inhibitor with IC50 values of 22 and 48 nM for ACC1 and ACC2, respectively. ACC1/2-IN-2 has antiproliferation activity and can be used for cancer research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
48 nM
Compound: 1
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay
[PMID: 22148323]
CHO IC50
48 nM
Compound: 17
Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader
Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader
[PMID: 20219367]
分子量

403.47

Formula

C24H25N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ACC1/2-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACC1/2-IN-21031411-94-5Acetyl-CoA CarboxylaseACC, Acetyl Coenzyme A Carboxylaseacetyl-CoA inhibitorsanticancerACC1ACC2Inhibitorinhibitorinhibit

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