2. Cytoskeleton
  3. Myosin
  4. Adhibin

Adhibin 是 RhoGAP IX 类肌球蛋白 (RhoGAP class IX myosin) 的变构抑制剂，可抑制哺乳动物和无脊椎动物中的 Myo9 ATPase，IC50 分别为 2.5 µM 和 2.6 µM。Adhibin 与 ATPase 结合，干扰 myosin 的运动功能，阻断 RhoGTPase 相关信号通路，并影响细胞迁移、粘附和细胞分裂。Adhibin 可用于癌症转移研究。

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Adhibin Chemical Structure

Adhibin Chemical Structure

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Adhibin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Adhibin is an allosteric inhibitor for RhoGAP class IX myosin, that inhibits Myo9 ATPase in mammalian and invertebrate with IC50 of 2.5 µM and 2.6 µM. Adhibin binds to the ATPase of myosin, interfers with its motor function, blocks the RhoGTPase related signaling pathway, and affects the cell migration, adhesion and cell division. Adhibin can be used in research about cancer metastasis[1].

分子量

355.02

Formula

C13H9Br2NO
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Adhibin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AdhibinMyosinA549MLE-12B16-F1Caco-2HeLaNIH/3T3Calu-3DrosophilaBALB/cJRj mouseInhibitorinhibitorinhibit

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