2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. ADTL-EI1712

ADTL-EI1712 是一种口服有效的 ERK1 和 ERK5 的选择性双靶点抑制剂，1 μM 时对 ERK1/5 的抑制率分别为 93.54% 和 89.35%。ADTL-EI1712 可诱导调节性细胞死亡（一种依赖于基因编码机制激活的细胞死亡形式），以克服体外和体内特定癌细胞的补偿机制。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

ADTL-EI1712 Chemical Structure

ADTL-EI1712 Chemical Structure

CAS No. : 2414916-45-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥2790
3 - 4 周
10 mg ￥4770
3 - 4 周
25 mg 现货 3 - 4 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

ADTL-EI1712 相关抗体

Top Publications Citing Use of Products

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
> 50 μM
Compound: 22ac; ADTL-EI1712
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
[PMID: 32078308]
HL-60 IC50
1.26 μM
Compound: 22ac; ADTL-EI1712
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
[PMID: 32078308]
MKN-74 IC50
2.55 μM
Compound: 22ac; ADTL-EI1712
Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
[PMID: 32078308]
体外研究
(In Vitro)

ADTL-EI1712 对 HL-60、MKN-74 和 HeLa 细胞具有抗增殖活性，IC50 值分别为 1.26+0.57、2.55+0.66、>50 μM[1]。
ADTL-EI1712 (0.5 μM, 24 h) 可在 MKN-74 细胞中诱导受调节的细胞死亡并伴有自噬 (autophagy)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ADTL-EI1712 相关抗体:
体内研究
(In Vivo)

ADTL-EI1712 (50 mg/kg，口服，每天一次，持续16天) 显著抑制 HL-60 和 MKN-74 细胞异种移植小鼠模型中的肿瘤体积，而 HeLa 细胞组的抗肿瘤作用要弱得多< sup>[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

505.44

Formula

C22H18Cl2N4O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ADTL-EI1712 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADTL-EI17122414916-45-1ERKExtracellular signal regulated kinasesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ADTL-EI1712
目录号：
HY-138215
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z