2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. ADWX 1 TFA

ADWX 1 TFA 是一种强效靶向抑制 Kv1.3的新型肽，IC50 值为1.89 pM。ADWX 1 特异性抑制 Kv1.3 通道活性，并抑制初始钙信号传导和 NF-κB 激活。ADWX 1 TFA 改善大鼠实验性自身免疫性脑脊髓炎 (experimental autoimmune encephalomyelitis, EAE) 疾病。ADWX 1 TFA 用于研究 T 细胞介导的自身免疫性疾病。

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Custom Peptide Synthesis

ADWX 1 TFA Chemical Structure

ADWX 1 TFA Chemical Structure

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Other Forms of ADWX 1 TFA:

ADWX 1 TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ADWX 1 TFA is a new peptide inhibitor that is potent and selective for Kv1.3 with an IC50 value of 1.89 pM. ADWX 1 inhibits Kv1.3 channel activity specifically to inhibit both the initial calcium signaling and NF-κB activation. ADWX 1 TFA ameliorates the disease in rats of experimental autoimmune encephalomyelitis (EAE) models. ADWX 1 TFA can be used to study T cell-mediated autoimmune diseases[1][2].

IC50 & Target[1]

Kv1.3

1.89 pM (IC50)

Kv1.1

0.65 nM (IC50)

体外研究
(In Vitro)

ADWX 1 (1，10 nM，1 h) TFA 降低 IL-2 和 IFN-γ 水平，选择性抑制人CD4+ CCR7- TEM 细胞的激活[2]。
ADWX 1 (1，10 nM，50 min) TFA 降低来源于 EAE 大鼠中激活的 CD4+ CCR7- TCM 细胞的 [Ca2+] 水平[2]。
ADWX 1 (1，10 nM，1 h) TFA 抑制来源于 EAE 大鼠中髓鞘碱性蛋白 (myelin basic protein, MBP) (HY-P77995) 激活的 CD4+ CCR7- T 细胞中 NF-κB 的激活，并特异降低 Kv1.3 基因和蛋白的水平[2]。
ADWX 1 (1，10 nM，3 天) TFA 抑制 CD4+ CCR7- T 细胞中 Th17 的激活但不抑制分化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ADWX 1 TFA 相关抗体:

RT-PCR[2]

Cell Line: CD4+ CCR7- T cells from EAE rats.
Concentration: 1, 10 nM, 10 nM.
Incubation Time: 1 h.
Result: Suppressed Kv1.3 gene mRNA expression preferentially.

Western Blot Analysis[2]

Cell Line: CD4+ CCR7- T cells from EAE rats
Concentration: 1, 10 nM.
Incubation Time: 1 h.
Result: Suppressed Kv1.3 protein expression preferentially.
体内研究
(In Vivo)

ADWX 1 (100 μg/kg/day，皮下注射，3天) 通过抑制 Sprague-Dawley 大鼠实验性自身免疫性脑脊髓炎(EAE) 模型中 IL-2 和 IFN-γ 的产生以及抑制 CCR7- TEM 细胞的增殖改善疾病[2]。
ADWX 1 (5/10 mg/kg，口服，2 周) 未诱导大鼠行为或组织发生病理变化 (急性毒性实验)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Stable symptoms of acute experimental autoimmune encephalomyelitis (EAE) were induced by immunizing Sprague-Dawley rats[2].
Dosage: 100 μg/kg/day, 3 days
Administration: Subcutaneous injection (s.c.).
Result: Reduced neurological scores compared with vehicle-treated rats on days 10, 11, 12, 13 and 14.
Reduced in inflammatory infiltrates and demyelination in the affected spinal cord significantly.
Inhibited IL-2 and IFN-γ productions.
Inhibited the T cell proliferation triggered by high and low concentrations of myelin antigen in a dose-dependent manner.
Decreased CD4+ CCR7- TEM cells.
分子量

4071.85 (free base)

Formula

C169H281N57O46S7.xC2HF3O2
Sequence

Val-Gly-Ile-Asn-Val-Lys-Cys-Lys-His-Ser-Arg-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Thr-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys (Disulfide bonds: Cys7-Cys27, Cys13-Cys32, Cys17-Cys34)
Sequence Shortening

VGINVKCKHSRQCLKPCKDAGMRFGKCTNGKCHCTPK (Disulfide bonds: Cys7-Cys27, Cys13-Cys32, Cys17-Cys34)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ADWX 1 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADWX 1ADWX1ADWX-1Potassium ChannelKcsAKv1.3calcium signalingautoimmuneIL-2IFN-γCD4Inhibitorinhibitorinhibit

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