2. Anti-infection
  3. Bacterial Fungal Antibiotic
  4. Aerothionin

Aerothionin 是一种对细菌和真菌具有有效抗菌作用的抗生素。Aerothionin 对肾上腺嗜铬细胞瘤和肾上腺外副神经节瘤 (PPGLs) 具有抗肿瘤作用。

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Aerothionin Chemical Structure

Aerothionin Chemical Structure

CAS No. : 28714-26-3

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Aerothionin 相关抗体

Top Publications Citing Use of Products

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aerothionin is an antibiotic with potent antimicrobial efficacy against bacteria and fungi. Aerothionin exhibits antitumor efficacy against adrenal pheochromocytomas and extra-adrenal paragangliomas (PPGLs)[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
> 10 μg/mL
Compound: 4
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 17512741]
HeLa IC50
29 μM
Compound: 2
Antiproliferative activity against human HeLa cells assessed as cell viability measured after 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell viability measured after 24 hrs by MTT assay
[PMID: 33940466]
HT-29 GI50
> 10 μg/mL
Compound: 4
Cytotoxicity against human HT29 cells by SRB assay
Cytotoxicity against human HT29 cells by SRB assay
[PMID: 17512741]
MDA-MB-231 GI50
> 10 μg/mL
Compound: 4
Cytotoxicity against human MDA-MB-231 cells by SRB assay
Cytotoxicity against human MDA-MB-231 cells by SRB assay
[PMID: 17512741]
体外研究
(In Vitro)

Aerothionin (0-100 μM, 24h) 抑制嗜铬细胞瘤细胞 MPC 和 MTT 的增殖，抑制 MTT 细胞球体生长 (10 μM) [1]。
Aerothionin (0-100 μM, 24h) 对正常内皮细胞 HUVECs 表现出毒性，轻微刺激正常成纤维细胞 3T3[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aerothionin 相关抗体:

Cell Viability Assay[1]

Cell Line: MPC, MTT, HUVECs, 3T3
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Inhibited proliferations of MPC, MTT and HUVECs, stimulated proliferation of 32T3.
分子量

818.10

Formula

C24H26Br4N4O8
CAS 号
结构分类
初始来源

Aplysina fistularis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aerothionin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aerothionin28714-26-3BacterialFungalAntibioticHUVECs3T3MPCMTTextra-adrenal paragangliomasPPGLInhibitorinhibitorinhibit

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