2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Afacifenacin

Afacifenacin  (Synonyms: SMP-986)

目录号: HY-14828
产品使用指南

摩尔计算器

Afacifenacin (SMP-986) 是一种有效的，具有口服活性的 毒蕈碱受体 (muscarinic receptor ) 拮抗剂。Afacifenacin 通过钠通道阻断抑制膀胱传入通路，增加容量，减少排尿和失禁的频率。Afacifenacin 具有用于膀胱过度活动症 (OAB) 研究的潜力。

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Afacifenacin Chemical Structure

Afacifenacin Chemical Structure

CAS No. : 877606-63-8

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Afacifenacin 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Afacifenacin (SMP-986) is a potent and orally active muscarinic receptor antagonist. Afacifenacin inhibits the bladder afferent pathway through the sodium-channel blockade, increasing volume, and reducing the frequency of urination and incontinence. Afacifenacin has the potential for the research of overactive bladder (OAB)[1][2].

体内研究
(In Vivo)

Afacifenacin (0.3, 1, 3 mg/kg; Intragastric administration) 显着增加脑梗死大鼠的膀胱容量和降低排尿压力 (MP)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (cerebral infarction model)[2]
Dosage: 0.3, 1, 3 mg/kg
Administration: Intragastric administration
Result: Significantly increased bladder capaticy and reduced micturition pressure (MP) without affecting residual urinary volume (RUV).
分子量

481.51

Formula

C27H26F3N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Afacifenacin 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Afacifenacin877606-63-8SMP-986SMP986SMP 986mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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