2. Anti-infection
  3. Bacterial Antibiotic
  4. AFN-1252 tosylate

AFN-1252 tosylate  (Synonyms: API-1252 tosylate; Debio 1452 tosylate)

目录号: HY-114622
产品使用指南

摩尔计算器

AFN-1252 tosylate 是一种具有口服活性的，选择性 FabI 抑制剂，FabI 是葡萄球菌属脂肪酸生物合成的必需酶。AFN-1252 tosylate 对葡萄球菌表现出高度选择性活性。AFN-1252 tosylate 对金黄色葡萄球菌的不同临床分离株的 MIC90 值 ?0.015 μg/ml。AFN-1252 tosylate 在败血症小鼠模型中有效，可提供 100% 的保护，防止金黄色葡萄球菌的致命腹膜感染。

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AFN-1252 tosylate Chemical Structure

AFN-1252 tosylate Chemical Structure

CAS No. : 1047981-31-6

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AFN-1252 tosylate 的其他形式现货产品:

Other Forms of AFN-1252 tosylate:

AFN-1252 tosylate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AFN-1252 (API-1252) tosylate is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 tosylate exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 tosylate exhibits typical MIC90 values of ?0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 tosylate is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith[1][2].

分子量

547.62

Formula

C29H29N3O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AFN-1252 tosylate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AFN-12521047981-31-6API-1252Debio 1452AFN1252AFN 1252API1252API 1252Debio1452Debio-1452BacterialAntibioticOrallyFabIfatty acid biosynthesisStaphylococcusS. aureussepticemiaInhibitorinhibitorinhibit

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