2. Protein Tyrosine Kinase/RTK
  3. PDGFR FLT3
  4. AGL 2043

AGL 2043 是有效的 PDGFR (IC50=0.8 μM) 和 TEL-PDGFR 激酶抑制剂，也是 FLT3 和 KIT 激酶抑制剂。AGL 2043 能有效抑制猪心脏平滑肌细胞增殖和球囊诱导的血管狭窄，适合开发为抗再狭窄和抗癌剂。

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AGL 2043 Chemical Structure

AGL 2043 Chemical Structure

CAS No. : 226717-28-8

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AGL 2043 相关抗体

Top Publications Citing Use of Products

查看 PDGFR 亚型特异性产品:

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PDGFR PDGFRβ PDGFRα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AGL 2043 is an effective inhibitor of PDGFR (IC50=0.8 μM) and TEL-PDGFR kinases, as well as FLT3 and KIT kinases. AGL 2043 can effectively inhibit porcine cardiac smooth muscle cell proliferation and balloon-induced vascular stenosis, and is suitable for development as an anti-restenotic and anticancer agent[1].

IC50 & Target

IC50: 0.8 μM (PDGFR)[1].
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BaF3 IC50
1 μM
Compound: 27; AGL 2043
Inhibition of human FLT3 expressed in mouse BAF3 cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by FLT3 ligand stimulation by immunoblot analysis
Inhibition of human FLT3 expressed in mouse BAF3 cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by FLT3 ligand stimulation by immunoblot analysis
[PMID: 30502116]
NIH3T3 IC50
> 30 μM
Compound: 27; AGL 2043
Inhibition of SRC in transformed mouse NIH3T3 cells by SDS-PAGE based immunoblot assay
Inhibition of SRC in transformed mouse NIH3T3 cells by SDS-PAGE based immunoblot assay
[PMID: 30502116]
分子量

280.35

Formula

C15H12N4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AGL 2043 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGL 2043226717-28-8AGL2043AGL-2043PDGFRFLT3Platelet-derived growth factor receptorCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3anticancer activityvascular restenosisInhibitorinhibitorinhibit

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目录号：
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