2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. AGN 193109 sodium

AGN 193109 sodium 是 AGN 193109 (HY-U00449) 的钠盐形式。AGN 193109 sodium 是视黄酸受体 (retinoic acid receptor, RAR) 的泛拮抗剂，对 RARα、RARβ 和 RARγ 的 Kd 分别为 2、2 和 3 nM。AGN 193109 sodium 可逆转 TTNPB 诱导的形态变化和全反式视黄酸 (all-trans retinoic acid, tRA)/9-cis RA/13-cis RA 诱导的 ECE16-1 细胞增殖抑制。AGN 193109 sodium 是视黄酸中毒的解毒剂，可改善皮肤和粘膜毒性。

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AGN 193109 sodium Chemical Structure

AGN 193109 sodium Chemical Structure

CAS No. : 2319838-82-7

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AGN 193109 sodium 的其他形式现货产品:

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AGN 193109 sodium 相关抗体

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RXRα RXRβ RXRγ

  • 生物活性

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生物活性

AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with Kd of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity[1][2].

IC50 & Target

RXR α

2 nM (Kd)

RXR β

2 nM (Kd)

RXR γ

2 nM (Kd)

分子量

414.47

Formula

C28H23NaO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AGN 193109 sodium 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

AGN 1931092319838-82-7AGN193109AGN-193109RAR/RXRRetinoic acid receptorsRetinoid X receptorsECE16-1Inhibitorinhibitorinhibit

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