2. PI3K/Akt/mTOR
  3. Akt
  4. AKT-IN-13

AKT-IN-13 (compound 4b) 是一种有效的 Akt 抑制剂，对 Akt1、Akt2 和 Akt3 的 IC50 分别为 1.6 nM、2.4 nM 和 0.3 nM。AKT-IN-13 可用于抗癌研究。

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AKT-IN-13 Chemical Structure

AKT-IN-13 Chemical Structure

CAS No. : 2459489-51-9

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AKT-IN-13 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AKT-IN-13 (compound 4b) is a potent Akt inhibitor with IC50s of 1.6 nM, 2.4 nM and 0.3 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-13 can be used for researching anticancer[1].

IC50 & Target[1]

Akt1

1.6 nM (IC50)

Akt2

2.4 nM (IC50)

Akt3

0.3 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
LNCaP IC50
103 nM
Compound: 4b
Antiproliferative activity against human LNcap assessed as reduction in cell viability incubated for 72 hrs by Cell Titer Glo luminescent assay
Antiproliferative activity against human LNcap assessed as reduction in cell viability incubated for 72 hrs by Cell Titer Glo luminescent assay
[PMID: 35679512]
体外研究
(In Vitro)

AKT-IN-13 (compound 4b) displays good potency in the LNCap cell line with an IC50 value of 103 nM and a high free fraction with 51.3% human plasma protein binding (PPB)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AKT-IN-13 相关抗体:
分子量

470.99

Formula

C24H31ClN6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AKT-IN-13 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT-IN-132459489-51-9AktPKBProtein kinase BanticancerLNCapInhibitorinhibitorinhibit

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产品名称：
AKT-IN-13
目录号：
HY-147937
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