2. PI3K/Akt/mTOR
  3. Akt
  4. AKT-IN-17

AKT-IN-17 是一种可口服的 AKt 抑制剂。AKT-IN-17 抑制 A549 细胞内的 AKt 使细胞凋亡 (Apoptosis)。AKT-IN-17 可用于非小细胞肺癌的研究。

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AKT-IN-17 Chemical Structure

AKT-IN-17 Chemical Structure

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AKT-IN-17 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AKT-IN-17 is a AKt inhibitor. AKT-IN-17 inhibits AKt in A549 cells, leading to Apoptosis. AKT-IN-17 can be used in non-small cell lung cancer study[1].

IC50 & Target[1]

AKt

105.88 μM (IC50)

体外研究
(In Vitro)

AKT-IN-17 (176.32 μM) 对 A549 细胞具有细胞毒活性，对正常细胞 L929 无影响，IC50 为 176.32 μM[1]。
AKT-IN-17 (44.06, 88.12, and 176.23 μM, 24 h) 抑制 A549 细胞内 AKt 的 IC50 为 105.88μM[1]。
AKT-IN-17 (176.23 μM, 24 h) 诱导 A549 细胞早期凋亡 3.26%，晚期凋亡 1.76%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AKT-IN-17 相关抗体:

Apoptosis Analysis[1]

Cell Line: A549
Concentration: 176.23 μM
Incubation Time: 24 h
Result: Induced early apoptosis of 3.26% and late apoptosis of 1.76% in A549 cells
分子量

428.94

Formula

C21H21ClN4O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AKT-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT-IN-17AktPKBProtein kinase BAKt InhibitorA549AKtApoptosisnon-small-cell lung carcinomaInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-149841
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