2. PI3K/Akt/mTOR Apoptosis
  3. Akt Apoptosis
  4. AKT-IN-18

AKT-IN-18 是一种 Akt 抑制剂，在 A549 细胞中抑制 Akt，IC50 为 69.45 μΜ。AKT-IN-18 诱导细胞凋亡 (apoptosis)，可用于非小细胞肺癌研究。

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AKT-IN-18 Chemical Structure

AKT-IN-18 Chemical Structure

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AKT-IN-18 相关抗体

Top Publications Citing Use of Products

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AKT-IN-18, an inhibitor of Akt, inhibits Akt with an IC50 of 69.45 μΜ in A549 cells. AKT-IN-18 induces apoptosis and can be used in non-small cell lung cancer study[1].

IC50 & Target[1]

Akt

69.45 μM (IC50)

体外研究
(In Vitro)

AKT-IN-18 (Compound 3i) (0-500 μM；24 小时) 对 A549 细胞具有细胞毒性，并诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AKT-IN-18 相关抗体:

Apoptosis Analysis[1]

Cell Line: A549, L929 cells
Concentration: 0-500 μM
Incubation Time: 24 hours
Result: Exerted cytotoxic activity against A549 cells with IC50 of 83.59 μΜ without influencing normal (L929) cells at effective doses.
Induced early apoptosis caused at 2.7% and late apoptotic cells at 6.04%.
分子量

411.86

Formula

C19H14ClN5O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AKT-IN-18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKT-IN-18AktApoptosisPKBProtein kinase BAkt InhibitorA549L929Non-Small-Cell Lung CarcinomaInhibitorinhibitorinhibit

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产品名称：
AKT-IN-18
目录号：
HY-149842
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