1. Anti-infection PI3K/Akt/mTOR
  2. HCV PI4K
  3. AL-9

AL-9 是 PI4KIIIα 抑制剂,IC50 为 0.57 μM,可抑制 HCV 复制。

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AL-9 Chemical Structure

AL-9 Chemical Structure

CAS No. : 869218-90-6

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  • 生物活性

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  • 参考文献

生物活性

AL-9 is a inhibitor of PI4KIIIα, with the IC50 of 0.57 μM, that can inhibit HCV replication[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 EC50
0.29 μM
Compound: AL-9
Antiviral activity against HCV genotype 1b infected in human Huh7.5 cells assessed as inhibition of viral replication after 72 hrs by real time PCR analysis
Antiviral activity against HCV genotype 1b infected in human Huh7.5 cells assessed as inhibition of viral replication after 72 hrs by real time PCR analysis
[PMID: 24900715]
Sf9 IC50
0.57 μM
Compound: AL-9
Inhibition of PI4K3alpha catalytic domain (unknown origin) expressed in baculovirus-infected Sf9 cells using PI:PS as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by ADP-Glo kinase assay
Inhibition of PI4K3alpha catalytic domain (unknown origin) expressed in baculovirus-infected Sf9 cells using PI:PS as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by ADP-Glo kinase assay
[PMID: 24900715]
Sf9 IC50
3.08 μM
Compound: AL-9
Inhibition of PI4K3beta (unknown origin) expressed in baculovirus-infected Sf9 cells using PI:PS as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by ADP-Glo kinase assay
Inhibition of PI4K3beta (unknown origin) expressed in baculovirus-infected Sf9 cells using PI:PS as substrate incubated for 10 mins followed by substrate addition measured after 1 hr by ADP-Glo kinase assay
[PMID: 24900715]
分子量

402.45

Formula

C23H22N4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AL-9
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HY-118525
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