2. GPCR/G Protein
  3. GLP Receptor
  4. Albenatide

Albenatide  (Synonyms: 艾本那肽; CJC 1134PC)

目录号: HY-120828
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摩尔计算器

Albenatide (CJC 1134PC) 是一种经过修饰的 Exendin-4 (HY-13443) 类似物，体外与人重组白蛋白 (HRA) 结合，形成长效 DPP-4 抗性 GLP-1R 激动剂。Albenatide 通过低分子化学接头 (cys-C13H19O6N3-lys) 与 HRA 34 位半胱氨酸残基共价结合。Albenatide 体外增加环磷酸腺苷 (cAMP) 的产生。Albenatide 降低了野生型小鼠的血糖波动、食物摄入量和胃排空，并提高了高脂饮食小鼠的血糖耐受性和减轻体重。

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Albenatide Chemical Structure

Albenatide Chemical Structure

CAS No. : 1031700-39-6

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Albenatide 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Albenatide (CJC 1134PC) is a modified Exendin-4 (HY-13443) analogue conjugated to human recombinant albumin (HRA) in vitro to form a long-acting DPP-4-resistant GLP-1R agonist. Albenatide covalently binds through a low-molecular chemical linker (cys-C13H19O6N3-lys) to the cysteine residue in position 34 of HRA. Albenatide increases cyclic AMP (cAMP) production in vitro. Albenatide reduces glucose excursions, food intake, gastric emptying in wild-type mice and improves glucose tolerance and reduces body weight in high-fat diet mice[1].

CAS 号
中文名称

艾本那肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Albenatide 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Albenatide1031700-39-6CJC 1134PC艾本那肽GLP ReceptorAlbuminHRADPP-4cys-C13H19O6N3-lyscyclic AMPcAMPglucose excursionsfood intakegastric emptyinghigh-fat dietInhibitorinhibitorinhibit

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