2. Apoptosis
  3. Apoptosis Caspase
  4. ALC67

ALC67 是一种具有细胞毒性的噻唑烷化合物，对肝脏、乳腺癌、结肠癌和子宫内膜癌细胞系的 IC50 约为 5 μM。ALC67 通过激活 caspase-9，阻滞 SubG1/G1 细胞周期，从而导致癌细胞凋亡 (Apoptosis)，该途径不依赖于死亡受体。ALC67 可用于抗癌领域的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ALC67 Chemical Structure

ALC67 Chemical Structure

CAS No. : 1044255-57-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

ALC67 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALC67 is a cytotoxic thiazolidine compound with an IC50 of approximately 5 μM against liver, breast cancer, colon cancer, and endometrial cancer cell lines. ALC67 induces apoptosis in cancer cells by activating caspase-9 and causing cell cycle arrest at the SubG1/G1 phase, via a pathway that is independent of death receptors. ALC67 can be used in cancer research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BT-20 IC50
1.6 μM
Compound: 3, ALC67
Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay
Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay
[PMID: 22867707]
CAMA-1 IC50
0.01 μM
Compound: 3, ALC67
Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay
Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay
[PMID: 22867707]
HCT-116 IC50
9.23 μM
Compound: 3, ALC67
Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay
Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay
[PMID: 22867707]
HepG2 IC50
10 μM
Compound: 3, ALC67
Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay
Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay
[PMID: 22867707]
Huh-7 IC50
5.3 μM
Compound: 3, ALC67
Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay
Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay
[PMID: 22867707]
MCF7 IC50
4.7 μM
Compound: 3, ALC67
Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay
[PMID: 22867707]
MFE-296 IC50
0.5 μM
Compound: 3, ALC67
Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay
Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay
[PMID: 22867707]
T47D IC50
7.62 μM
Compound: 3, ALC67
Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay
Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay
[PMID: 22867707]
分子量

289.35

Formula

C15H15NO3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALC67 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALC671044255-57-3ALC 67ALC-67ApoptosisCaspaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ALC67
目录号：
HY-117047
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z